Nucleophilic aromatic substitution reactions under aqueous, mild conditions using polymeric additive HPMC

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2021
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Ansari, Tharique N.
Braje, Leon H.
Ogulu, Deborah
Handa, Sachin
Braje, Wilfried M.
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Green Chemistry. Royal Society of Chemistry (RSC). 2021, 23(11), pp. 3955-3962. ISSN 1463-9262. eISSN 1463-9270. Available under: doi: 10.1039/D1GC00128K
Zusammenfassung

The use of the inexpensive, benign, and sustainable polymer, hydroxypropyl methylcellulose (HPMC), in water enables nucleophilic aromatic subsitution (SNAr) reactions between various nucleophiles and electrophiles. The mild reaction conditions facilitate a broad functional group tolerance that can be utilized for subsequent derivatization for the synthesis of pharmaceutically relevant building blocks. The use of only equimolar amounts of all reagents and water as reaction solvent reveals the greenness and sustainability of the methodology presented herein.

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ISO 690BORLINGHAUS, Niginia, Tharique N. ANSARI, Leon H. BRAJE, Deborah OGULU, Sachin HANDA, Valentin WITTMANN, Wilfried M. BRAJE, 2021. Nucleophilic aromatic substitution reactions under aqueous, mild conditions using polymeric additive HPMC. In: Green Chemistry. Royal Society of Chemistry (RSC). 2021, 23(11), pp. 3955-3962. ISSN 1463-9262. eISSN 1463-9270. Available under: doi: 10.1039/D1GC00128K
BibTex
@article{Borlinghaus2021-06-09Nucle-53710,
  year={2021},
  doi={10.1039/D1GC00128K},
  title={Nucleophilic aromatic substitution reactions under aqueous, mild conditions using polymeric additive HPMC},
  number={11},
  volume={23},
  issn={1463-9262},
  journal={Green Chemistry},
  pages={3955--3962},
  author={Borlinghaus, Niginia and Ansari, Tharique N. and Braje, Leon H. and Ogulu, Deborah and Handa, Sachin and Wittmann, Valentin and Braje, Wilfried M.}
}
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