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Gene and genome duplications in vertebrates : the one-to-four (-to-eight in fish) rule and the evolution of novel gene functions

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Gene_and_genome_duplications_in_vertebrates_.pdf
Gene_and_genome_duplications_in_vertebrates_.pdfGröße: 276.37 KBDownloads: 1932

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1999

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Schartl, Manfred

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Current Opinion in Cell Biology. 1999, 11(6), pp. 699-704. ISSN 0955-0674. Available under: doi: 10.1016/S0955-0674(99)00039-3

Zusammenfassung

One important mechanism for functional innovation during evolution is the duplication of genes and entire genomes. Evidence is accumulating that during the evolution of vertebrates from early deuterostome ancestors entire genomes were duplicated through two rounds of duplications (the oneto- two-to-four rule). The first genome duplication in chordate evolution might predate the Cambrian explosion. The second genome duplication possibly dates back to the early Devonian. Recent data suggest that later in the Devonian, the fish genome was duplicated for a third time to produce up to eight copies of the original deuterostome genome. This last duplication took place after the two major radiations of jawed vertebrate life, the ray-finned fish (Actinopterygia) and the sarcopterygian lineage, diverged. Therefore the sarcopterygian fish, which includes the coelacanth, lungfish and all land vertebrates such as amphibians, reptiles, birds and mammals, tend to have only half the number of genes compared with actinopterygian fish. Although many duplicated genes turned into pseudogenes, or even junk DNA, many others evolved new functions particularly during development. The increased genetic complexity of fish might reflect their evolutionary success and diversity.

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570 Biowissenschaften, Biologie

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ISO 690MEYER, Axel, Manfred SCHARTL, 1999. Gene and genome duplications in vertebrates : the one-to-four (-to-eight in fish) rule and the evolution of novel gene functions. In: Current Opinion in Cell Biology. 1999, 11(6), pp. 699-704. ISSN 0955-0674. Available under: doi: 10.1016/S0955-0674(99)00039-3
BibTex
@article{Meyer1999genom-8161,
  year={1999},
  doi={10.1016/S0955-0674(99)00039-3},
  title={Gene and genome duplications in vertebrates : the one-to-four (-to-eight in fish) rule and the evolution of novel gene functions},
  number={6},
  volume={11},
  issn={0955-0674},
  journal={Current Opinion in Cell Biology},
  pages={699--704},
  author={Meyer, Axel and Schartl, Manfred}
}
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    <dcterms:abstract xml:lang="eng">One important mechanism for functional innovation during evolution is the duplication of genes and entire genomes. Evidence is accumulating that during the evolution of vertebrates from early deuterostome ancestors entire genomes were duplicated through two rounds of duplications (the  oneto- two-to-four  rule). The first genome duplication in chordate evolution might predate the Cambrian explosion. The second genome duplication possibly dates back to the early Devonian. Recent data suggest that later in the Devonian, the fish genome was duplicated for a third time to produce up to eight copies of the original deuterostome genome. This last duplication took place after the two major radiations of jawed vertebrate life, the ray-finned fish (Actinopterygia) and the sarcopterygian lineage, diverged. Therefore the sarcopterygian fish, which includes the coelacanth, lungfish and all land vertebrates such as amphibians, reptiles, birds and mammals, tend to have only half the number of genes compared with actinopterygian fish. Although many duplicated genes turned into pseudogenes, or even  junk  DNA, many others evolved new functions particularly during development. The increased genetic complexity of fish might reflect their evolutionary success and diversity.</dcterms:abstract>
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