Publikation: Disruption of Tumor Cell Adhesion Promotes Angiogenic Switch and Progression to Micrometastasis in RAF-Driven Murine Lung Cancer
Lade...
Dateien
Zu diesem Dokument gibt es keine Dateien.
Datum
2007
Autor:innen
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
DOI (zitierfähiger Link)
Internationale Patentnummer
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Sammlungen
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
Cancer Cell. 2007, 12(2), pp. 145-159. ISSN 1535-6108. eISSN 1878-3686. Available under: doi: 10.1016/j.ccr.2007.06.014
Zusammenfassung
Progression of non-small-cell lung cancer (NSCLC) to metastasis is poorly understood. Two genetic approaches were used to evaluate the role of adherens junctions in a C-RAF driven mouse model for NSCLC: conditional ablation of the cdh1 gene and expression of dominant-negative (dn) E-cadherin. Disruption of E-cadherin caused massive formation of intratumoral vessels that was reversible in the early phase of induction. Vascularized tumors grew more rapidly, developed invasive fronts, and gave rise to micrometastasis. beta-catenin was identified as a critical effector of E-cadherin disruption leading to upregulation of VEGF-A and VEGF-C. In vivo, lung tumor cells with disrupted E-cadherin expressed beta-catenin target genes normally found in other endodermal lineages suggesting that reprogramming may be involved in metastatic progression.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690
CETECI, Fatih, Semra CETECI, Christiaan KARREMAN, Boris W. KRAMER, Esther ASAN, Rudolf GÖTZ, Ulf R. RAPP, 2007. Disruption of Tumor Cell Adhesion Promotes Angiogenic Switch and Progression to Micrometastasis in RAF-Driven Murine Lung Cancer. In: Cancer Cell. 2007, 12(2), pp. 145-159. ISSN 1535-6108. eISSN 1878-3686. Available under: doi: 10.1016/j.ccr.2007.06.014BibTex
@article{Ceteci2007-08Disru-38680,
year={2007},
doi={10.1016/j.ccr.2007.06.014},
title={Disruption of Tumor Cell Adhesion Promotes Angiogenic Switch and Progression to Micrometastasis in RAF-Driven Murine Lung Cancer},
number={2},
volume={12},
issn={1535-6108},
journal={Cancer Cell},
pages={145--159},
author={Ceteci, Fatih and Ceteci, Semra and Karreman, Christiaan and Kramer, Boris W. and Asan, Esther and Götz, Rudolf and Rapp, Ulf R.}
}RDF
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bibo="http://purl.org/ontology/bibo/"
xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
xmlns:foaf="http://xmlns.com/foaf/0.1/"
xmlns:void="http://rdfs.org/ns/void#"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#" >
<rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/38680">
<dc:creator>Götz, Rudolf</dc:creator>
<dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-05-02T09:15:17Z</dcterms:available>
<dc:creator>Ceteci, Semra</dc:creator>
<dc:creator>Rapp, Ulf R.</dc:creator>
<dc:creator>Karreman, Christiaan</dc:creator>
<dc:contributor>Götz, Rudolf</dc:contributor>
<dc:contributor>Rapp, Ulf R.</dc:contributor>
<dc:creator>Kramer, Boris W.</dc:creator>
<dc:contributor>Asan, Esther</dc:contributor>
<dc:contributor>Kramer, Boris W.</dc:contributor>
<dc:creator>Asan, Esther</dc:creator>
<dc:contributor>Ceteci, Semra</dc:contributor>
<foaf:homepage rdf:resource="http://localhost:8080/"/>
<dcterms:abstract xml:lang="eng">Progression of non-small-cell lung cancer (NSCLC) to metastasis is poorly understood. Two genetic approaches were used to evaluate the role of adherens junctions in a C-RAF driven mouse model for NSCLC: conditional ablation of the cdh1 gene and expression of dominant-negative (dn) E-cadherin. Disruption of E-cadherin caused massive formation of intratumoral vessels that was reversible in the early phase of induction. Vascularized tumors grew more rapidly, developed invasive fronts, and gave rise to micrometastasis. beta-catenin was identified as a critical effector of E-cadherin disruption leading to upregulation of VEGF-A and VEGF-C. In vivo, lung tumor cells with disrupted E-cadherin expressed beta-catenin target genes normally found in other endodermal lineages suggesting that reprogramming may be involved in metastatic progression.</dcterms:abstract>
<dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
<void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
<dc:creator>Ceteci, Fatih</dc:creator>
<dc:contributor>Ceteci, Fatih</dc:contributor>
<bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/38680"/>
<dc:contributor>Karreman, Christiaan</dc:contributor>
<dc:language>eng</dc:language>
<dcterms:title>Disruption of Tumor Cell Adhesion Promotes Angiogenic Switch and Progression to Micrometastasis in RAF-Driven Murine Lung Cancer</dcterms:title>
<dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
<dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-05-02T09:15:17Z</dc:date>
<dcterms:issued>2007-08</dcterms:issued>
</rdf:Description>
</rdf:RDF>Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
