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A beta-lactone-based antivirulence drug ameliorates Staphylococcus aureus skin infections in mice

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2014

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Weinandy, Franziska
Lorenz-Baath, Katrin
Korotkov, Vadim S.
Sethi, Shneh
Chakraborty, Trinad
Sieber, Stephan A.

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http://nbn-resolving.de/urn:nbn:de:bsz:352-284276
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https://doi.org/10.1002/cmdc.201300325
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Open Access-Veröffentlichung

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Chemie: Publikationen
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ChemMedChem. 2014, 9(4), pp. 710-713. ISSN 1860-7179. eISSN 1860-7187. Available under: doi: 10.1002/cmdc.201300325

Zusammenfassung

Skin infections caused by Staphylococcus aureus are a major clinical concern, especially if they are caused by multi-resistant strains. In these cases, a spread into deeper soft tissues or the bloodstream results in life-threatening conditions that are difficult to treat by conventional antibiotics. Previous in vitro experiments with a small β-lactone-based molecule demonstrated that antibiotic-sensitive and -resistant S. aureus strains are effectively disarmed in their virulence and corresponding pathogenicity. In this work, in vivo mouse studies show that this methodology is effective for the treatment of skin abscesses in mice. A single dose of the β-lactone significantly decreased abscess size even when applied 6 h post-infection. Although the molecule requires pharmacological optimization (improved stability, for example), this study emphasizes the potential value of antivirulence therapies.

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540 Chemie

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ISO 690WEINANDY, Franziska, Katrin LORENZ-BAATH, Vadim S. KOROTKOV, Thomas BÖTTCHER, Shneh SETHI, Trinad CHAKRABORTY, Stephan A. SIEBER, 2014. A beta-lactone-based antivirulence drug ameliorates Staphylococcus aureus skin infections in mice. In: ChemMedChem. 2014, 9(4), pp. 710-713. ISSN 1860-7179. eISSN 1860-7187. Available under: doi: 10.1002/cmdc.201300325
BibTex
@article{Weinandy2014-04betal-28427,
  year={2014},
  doi={10.1002/cmdc.201300325},
  title={A beta-lactone-based antivirulence drug ameliorates Staphylococcus aureus skin infections in mice},
  number={4},
  volume={9},
  issn={1860-7179},
  journal={ChemMedChem},
  pages={710--713},
  author={Weinandy, Franziska and Lorenz-Baath, Katrin and Korotkov, Vadim S. and Böttcher, Thomas and Sethi, Shneh and Chakraborty, Trinad and Sieber, Stephan A.}
}
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