Publikation:

CARMA1 is a critical lipid raft–associated regulator of TCR-induced NF-κB activation

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2002

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Gaide, Olivier
Favier, Benoît
Bonnet, David
Brissoni, Brian
Valitutti, Salvatore
Bron, Claude
Tschopp, Jürg
Thome, Margot

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Nature Immunology. 2002, 3(9), pp. 836-843. ISSN 1529-2908. eISSN 1529-2916. Available under: doi: 10.1038/ni830

Zusammenfassung

CARMA1 is a lymphocyte-specific member of the membrane-associated guanylate kinase (MAGUK) family of scaffolding proteins, which coordinate signaling pathways emanating from the plasma membrane. CARMA1 interacts with Bcl10 via its caspase-recruitment domain (CARD). Here we investigated the role of CARMA1 in T cell activation and found that T cell receptor (TCR) stimulation induced a physical association of CARMA1 with the TCR and Bcl10. We found that CARMA1 was constitutively associated with lipid rafts, whereas cytoplasmic Bcl10 translocated into lipid rafts upon TCR engagement. A CARMA1 mutant, defective for Bcl10 binding, had a dominant-negative (DN) effect on TCR-induced NF-kappa B activation and IL-2 production and on the c-Jun NH(2)-terminal kinase (Jnk) pathway when the TCR was coengaged with CD28. Together, our data show that CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation and CD28 costimulation-dependent Jnk activation.

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570 Biowissenschaften, Biologie

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ISO 690GAIDE, Olivier, Benoît FAVIER, Daniel F. LEGLER, David BONNET, Brian BRISSONI, Salvatore VALITUTTI, Claude BRON, Jürg TSCHOPP, Margot THOME, 2002. CARMA1 is a critical lipid raft–associated regulator of TCR-induced NF-κB activation. In: Nature Immunology. 2002, 3(9), pp. 836-843. ISSN 1529-2908. eISSN 1529-2916. Available under: doi: 10.1038/ni830
BibTex
@article{Gaide2002CARMA-36629,
  year={2002},
  doi={10.1038/ni830},
  title={CARMA1 is a critical lipid raft–associated regulator of TCR-induced NF-κB activation},
  number={9},
  volume={3},
  issn={1529-2908},
  journal={Nature Immunology},
  pages={836--843},
  author={Gaide, Olivier and Favier, Benoît and Legler, Daniel F. and Bonnet, David and Brissoni, Brian and Valitutti, Salvatore and Bron, Claude and Tschopp, Jürg and Thome, Margot}
}
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