Publikation: CARMA1 is a critical lipid raft–associated regulator of TCR-induced NF-κB activation
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CARMA1 is a lymphocyte-specific member of the membrane-associated guanylate kinase (MAGUK) family of scaffolding proteins, which coordinate signaling pathways emanating from the plasma membrane. CARMA1 interacts with Bcl10 via its caspase-recruitment domain (CARD). Here we investigated the role of CARMA1 in T cell activation and found that T cell receptor (TCR) stimulation induced a physical association of CARMA1 with the TCR and Bcl10. We found that CARMA1 was constitutively associated with lipid rafts, whereas cytoplasmic Bcl10 translocated into lipid rafts upon TCR engagement. A CARMA1 mutant, defective for Bcl10 binding, had a dominant-negative (DN) effect on TCR-induced NF-kappa B activation and IL-2 production and on the c-Jun NH(2)-terminal kinase (Jnk) pathway when the TCR was coengaged with CD28. Together, our data show that CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation and CD28 costimulation-dependent Jnk activation.
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GAIDE, Olivier, Benoît FAVIER, Daniel F. LEGLER, David BONNET, Brian BRISSONI, Salvatore VALITUTTI, Claude BRON, Jürg TSCHOPP, Margot THOME, 2002. CARMA1 is a critical lipid raft–associated regulator of TCR-induced NF-κB activation. In: Nature Immunology. 2002, 3(9), pp. 836-843. ISSN 1529-2908. eISSN 1529-2916. Available under: doi: 10.1038/ni830BibTex
@article{Gaide2002CARMA-36629, year={2002}, doi={10.1038/ni830}, title={CARMA1 is a critical lipid raft–associated regulator of TCR-induced NF-κB activation}, number={9}, volume={3}, issn={1529-2908}, journal={Nature Immunology}, pages={836--843}, author={Gaide, Olivier and Favier, Benoît and Legler, Daniel F. and Bonnet, David and Brissoni, Brian and Valitutti, Salvatore and Bron, Claude and Tschopp, Jürg and Thome, Margot} }
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