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A new anticoagulant-antidote pair : Control of thrombin activity by aptamers and porphyrins

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2007

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Mayer, Günter

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http://nbn-resolving.de/urn:nbn:de:bsz:352-156223
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https://doi.org/10.1021/ja0677822
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Journal of the American Chemical Society. 2007, 129(11), pp. 3036-3037. ISSN 0002-7863. Available under: doi: 10.1021/ja0677822

Zusammenfassung

Cationic porphyrins have been described to bind to G-quadruplexes with high affinities. In combination with G-quadruplex containing DNA aptamers that bind and inhibit the blood clotting factor thrombin, these molecules act as true antidotes that revert the anticoagulant activity of the aptamer. Porphyrins in concert with four-stranded aptamers therefore represent a novel anticoagulant/antidote class within the blood clotting cascade.

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ISO 690JOACHIMI, Astrid, Günter MAYER, Jörg S. HARTIG, 2007. A new anticoagulant-antidote pair : Control of thrombin activity by aptamers and porphyrins. In: Journal of the American Chemical Society. 2007, 129(11), pp. 3036-3037. ISSN 0002-7863. Available under: doi: 10.1021/ja0677822
BibTex
@article{Joachimi2007-03-21antic-15622,
  year={2007},
  doi={10.1021/ja0677822},
  title={A new anticoagulant-antidote pair : Control of thrombin activity by aptamers and porphyrins},
  number={11},
  volume={129},
  issn={0002-7863},
  journal={Journal of the American Chemical Society},
  pages={3036--3037},
  author={Joachimi, Astrid and Mayer, Günter and Hartig, Jörg S.}
}
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