Publikation: Measurement of air-borne pyrogens by the in vitro pyrogen test (IPT) based on human whole blood cytokine response
Dateien
Datum
Autor:innen
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
Internationale Patentnummer
Link zur Lizenz
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Sammlungen
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Publikationsstatus
Erschienen in
Zusammenfassung
The impact of environmental micro-organisms as well as their fragments and components, especially endotoxins, on human health is increasingly recognised. Different syndromes have been described in connection with inhaled air-borne microbiological contamination, e.g, sick building syndrome, humidifier lung, organic dust toxic syndrome (ODTS) and "Monday illness" . Air-conditioning systems intensify this problem, as does the collection of biological waste in households, which represents a substantial source of air-born e pollution. In 1995 we described a new method for the detect ion or pyrogenic contamination. This sensitive test (in vitro pyrogen test: IPT ) uses the natural reaction of the immune system to detect a broad spectrum of pyrogens in hum an blond. Safety tests in injectable drugs represent the ma in application and the test has been success fully validated for inclusion into the Euro pea n Pharmacopoeia. Here, the test was adapted to the detection of environmental air-borne pyrogens. Air was drawn through a filter which was then incubated directly with diluted human whole blood . The release of the inflammatory cytokine , interleukin-1β (IL-1β), was measured by ELlSA . ln animal stables, up to 3 x 106 endotoxin equivalent units (EEU) were found per cubic meter of air.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
Schlagwörter
Konferenz
Rezension
Zitieren
ISO 690
KINDINGER, Ilona, Stefan FENNRICH, Bert ZUCKER, Gunter LINSEL, Sonja von AULOCK, Thomas HARTUNG, 2003. Measurement of air-borne pyrogens by the in vitro pyrogen test (IPT) based on human whole blood cytokine response. In: European journal of parenteral and pharmaceutical sciences. 2003, 8(3), pp. 65-69BibTex
@article{Kindinger2003Measu-7165, year={2003}, title={Measurement of air-borne pyrogens by the in vitro pyrogen test (IPT) based on human whole blood cytokine response}, number={3}, volume={8}, journal={European journal of parenteral and pharmaceutical sciences}, pages={65--69}, author={Kindinger, Ilona and Fennrich, Stefan and Zucker, Bert and Linsel, Gunter and Aulock, Sonja von and Hartung, Thomas} }
RDF
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/7165"> <dc:format>application/pdf</dc:format> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7165/1/2003KindingerEJPPS_bearb.pdf"/> <dc:contributor>Linsel, Gunter</dc:contributor> <dc:contributor>Zucker, Bert</dc:contributor> <dc:creator>Fennrich, Stefan</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:32:21Z</dc:date> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7165"/> <dc:contributor>Hartung, Thomas</dc:contributor> <dcterms:title>Measurement of air-borne pyrogens by the in vitro pyrogen test (IPT) based on human whole blood cytokine response</dcterms:title> <dc:rights>Attribution-NonCommercial-NoDerivs 2.0 Generic</dc:rights> <dc:creator>Aulock, Sonja von</dc:creator> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:abstract xml:lang="eng">The impact of environmental micro-organisms as well as their fragments and components, especially endotoxins, on human health is increasingly recognised. Different syndromes have been described in connection with inhaled air-borne microbiological contamination, e.g, sick building syndrome, humidifier lung, organic dust toxic syndrome (ODTS) and "Monday illness" . Air-conditioning systems intensify this problem, as does the collection of biological waste in households, which represents a substantial source of air-born e pollution. In 1995 we described a new method for the detect ion or pyrogenic contamination. This sensitive test (in vitro pyrogen test: IPT ) uses the natural reaction of the immune system to detect a broad spectrum of pyrogens in hum an blond. Safety tests in injectable drugs represent the ma in application and the test has been success fully validated for inclusion into the Euro pea n Pharmacopoeia. Here, the test was adapted to the detection of environmental air-borne pyrogens. Air was drawn through a filter which was then incubated directly with diluted human whole blood . The release of the inflammatory cytokine , interleukin-1β (IL-1β), was measured by ELlSA . ln animal stables, up to 3 x 106 endotoxin equivalent units (EEU) were found per cubic meter of air.</dcterms:abstract> <dc:contributor>Fennrich, Stefan</dc:contributor> <dc:creator>Linsel, Gunter</dc:creator> <dc:contributor>Kindinger, Ilona</dc:contributor> <dc:language>eng</dc:language> <dc:creator>Zucker, Bert</dc:creator> <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc-nd/2.0/"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7165/1/2003KindingerEJPPS_bearb.pdf"/> <dcterms:bibliographicCitation>First publ. in: European journal of parenteral and pharmaceutical sciences 8 (2003), 3, pp. 65-69</dcterms:bibliographicCitation> <dcterms:issued>2003</dcterms:issued> <foaf:homepage rdf:resource="http://localhost:8080/"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dc:contributor>Aulock, Sonja von</dc:contributor> <dc:creator>Kindinger, Ilona</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:32:21Z</dcterms:available> <dc:creator>Hartung, Thomas</dc:creator> </rdf:Description> </rdf:RDF>