Publikation:

Cyclic Peptides as Scaffolds for Multivalent Presentation of Carbohydrates : a Combinatorial Approach

Lade...
Vorschaubild

Dateien

witt_014.pdf
witt_014.pdfGröße: 291.02 KBDownloads: 506

Datum

2001

Autor:innen

Seeberger, Sonja

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

DOI (zitierfähiger Link)
ArXiv-ID

Internationale Patentnummer

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung
Open Access Green
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Beitrag zu einem Sammelband
Publikationsstatus
Published

Erschienen in

EPTON, Roger, ed.. Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Libraries 2000. Kingswinford: Mayflower, 2001, pp. 355-358

Zusammenfassung

Carbohydrate lectin interactions mediate a large variety of intercellular recognition events. Since the interactions of individual saccharide groups are usually of low affinity and broad specificity, subsite and subunit multivalency is often employed by nature in order to enhance the attractive binding forces. Accordingly, the synthesis of multivalent carbohydrate ligands has recently attracted interest. Binding studies with these multivalent ligands revealed the importance of the spacer between the monomeric epitopes. Attachment of the saccharides to rigid scaffolds can result in particularly pronounced affinity enhancements provided that the sugars are presented in the correct spatial arrangement. However, in contrast to the utilization of flexible linkers, a larger number of ligands has to be screened in order to find a ligand with the
appropriate orientation of the carbohydrates.
Here we present a synthetic approach that enables the preparation of libraries of conformationally restricted cyclic peptides which can serve as scaffolds for the multivalent presentation of carbohydrate ligands [3]. Such libraries are useful to identify high affinity lectin ligands based on multivalent interactions and to determine the required orientation of the carbohydrates via conformational analysis of the cyclopeptide scaffold.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
540 Chemie

Schlagwörter

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690SEEBERGER, Sonja, Valentin WITTMANN, 2001. Cyclic Peptides as Scaffolds for Multivalent Presentation of Carbohydrates : a Combinatorial Approach. In: EPTON, Roger, ed.. Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Libraries 2000. Kingswinford: Mayflower, 2001, pp. 355-358
BibTex
@incollection{Seeberger2001Cycli-9725,
  year={2001},
  title={Cyclic Peptides as Scaffolds for Multivalent Presentation of Carbohydrates : a Combinatorial Approach},
  publisher={Mayflower},
  address={Kingswinford},
  booktitle={Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Libraries 2000},
  pages={355--358},
  editor={Epton, Roger},
  author={Seeberger, Sonja and Wittmann, Valentin}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/9725">
    <dcterms:abstract xml:lang="eng">Carbohydrate lectin interactions mediate a large variety of intercellular recognition events. Since the interactions of individual saccharide groups are usually of low affinity and broad specificity, subsite and subunit multivalency is often employed by nature in order to enhance the attractive binding forces. Accordingly, the synthesis of multivalent carbohydrate ligands has recently attracted interest. Binding studies with these multivalent ligands revealed the importance of the spacer between the monomeric epitopes. Attachment of the saccharides to rigid scaffolds can result in particularly pronounced affinity enhancements provided that the sugars are presented in the  correct  spatial arrangement. However, in contrast to the utilization of flexible linkers, a larger number of ligands has to be screened in order to find a ligand with the&lt;br /&gt;appropriate orientation of the carbohydrates.&lt;br /&gt;Here we present a synthetic approach that enables the preparation of libraries of conformationally restricted cyclic peptides which can serve as scaffolds for the multivalent presentation of carbohydrate ligands [3]. Such libraries are useful to identify high affinity lectin ligands based on multivalent interactions and to determine the required orientation of the carbohydrates via conformational analysis of the cyclopeptide scaffold.</dcterms:abstract>
    <dc:contributor>Seeberger, Sonja</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T18:13:58Z</dc:date>
    <dc:language>eng</dc:language>
    <dcterms:title>Cyclic Peptides as Scaffolds for Multivalent Presentation of Carbohydrates : a Combinatorial Approach</dcterms:title>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/9725/1/witt_014.pdf"/>
    <dcterms:issued>2001</dcterms:issued>
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc-nd/2.0/"/>
    <dc:creator>Wittmann, Valentin</dc:creator>
    <dcterms:bibliographicCitation>First publ. in: Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Libraries 2000 / ed. Roger Epton. Kingswinford: Mayflower 2001, pp. 355-358</dcterms:bibliographicCitation>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:format>application/pdf</dc:format>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T18:13:58Z</dcterms:available>
    <dc:rights>Attribution-NonCommercial-NoDerivs 2.0 Generic</dc:rights>
    <dc:contributor>Wittmann, Valentin</dc:contributor>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/9725/1/witt_014.pdf"/>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/9725"/>
    <dc:creator>Seeberger, Sonja</dc:creator>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
Begutachtet
Diese Publikation teilen