Activation of the glmS Ribozyme Confers Bacterial Growth Inhibition

Schüller, Anna; Matzner, Daniel; Lünse, Christina E.; Wittmann, Valentin; Schumacher, Catherine; Unsleber, Sandra; Brötz-Oesterhelt, Heike; Mayer, Christoph; Bierbaum, Gabriele; Mayer, Günter

Activation of the glmS Ribozyme Confers Bacterial Growth Inhibition

Dateien

Zu diesem Dokument gibt es keine Dateien.

Datum

2017

Autor:innen

Schüller, Anna

Matzner, Daniel

Lünse, Christina E.

Wittmann, Valentin

Schumacher, Catherine

Unsleber, Sandra

Brötz-Oesterhelt, Heike

Mayer, Christoph

Bierbaum, Gabriele

Mayer, Günter

DOI (zitierfähiger Link)

https://doi.org/10.1002/cbic.201600491

Sammlungen

Chemie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

ChemBioChem. 2017, 18(5), pp. 435-440. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201600491

Zusammenfassung

The ever-growing number of pathogenic bacteria resistant to treatment with antibiotics call for the development of novel compounds with as-yet unexplored modes of action. Here, we demonstrate the in vivo antibacterial activity of carba-α-d-glucosamine (CGlcN). In this mode of action study, we provide evidence that CGlcN-mediated growth inhibition is due to glmS ribozyme activation, and we demonstrate that CGlcN hijacks an endogenous activation pathway, hence utilizing a prodrug mechanism. This is the first report describing antibacterial activity mediated by activating the self-cleaving properties of a ribozyme. Our results open the path towards a compound class with an entirely novel and distinct molecular mechanism.

Fachgebiet (DDC)

540 Chemie

Zitieren

ISO 690

SCHÜLLER, Anna, Daniel MATZNER, Christina E. LÜNSE, Valentin WITTMANN, Catherine SCHUMACHER, Sandra UNSLEBER, Heike BRÖTZ-OESTERHELT, Christoph MAYER, Gabriele BIERBAUM, Günter MAYER, 2017. Activation of the glmS Ribozyme Confers Bacterial Growth Inhibition. In: ChemBioChem. 2017, 18(5), pp. 435-440. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201600491

BibTex

@article{Schuller2017-03-02Activ-37503,
  year={2017},
  doi={10.1002/cbic.201600491},
  title={Activation of the glmS Ribozyme Confers Bacterial Growth Inhibition},
  number={5},
  volume={18},
  issn={1439-4227},
  journal={ChemBioChem},
  pages={435--440},
  author={Schüller, Anna and Matzner, Daniel and Lünse, Christina E. and Wittmann, Valentin and Schumacher, Catherine and Unsleber, Sandra and Brötz-Oesterhelt, Heike and Mayer, Christoph and Bierbaum, Gabriele and Mayer, Günter}
}

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Universitätsbibliographie

Ja