Publikation: Activation of the glmS Ribozyme Confers Bacterial Growth Inhibition
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2017
Autor:innen
Schüller, Anna
Matzner, Daniel
Lünse, Christina E.
Schumacher, Catherine
Unsleber, Sandra
Brötz-Oesterhelt, Heike
Bierbaum, Gabriele
Mayer, Günter
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ChemBioChem. 2017, 18(5), pp. 435-440. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201600491
Zusammenfassung
The ever-growing number of pathogenic bacteria resistant to treatment with antibiotics call for the development of novel compounds with as-yet unexplored modes of action. Here, we demonstrate the in vivo antibacterial activity of carba-α-d-glucosamine (CGlcN). In this mode of action study, we provide evidence that CGlcN-mediated growth inhibition is due to glmS ribozyme activation, and we demonstrate that CGlcN hijacks an endogenous activation pathway, hence utilizing a prodrug mechanism. This is the first report describing antibacterial activity mediated by activating the self-cleaving properties of a ribozyme. Our results open the path towards a compound class with an entirely novel and distinct molecular mechanism.
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SCHÜLLER, Anna, Daniel MATZNER, Christina E. LÜNSE, Valentin WITTMANN, Catherine SCHUMACHER, Sandra UNSLEBER, Heike BRÖTZ-OESTERHELT, Christoph MAYER, Gabriele BIERBAUM, Günter MAYER, 2017. Activation of the glmS Ribozyme Confers Bacterial Growth Inhibition. In: ChemBioChem. 2017, 18(5), pp. 435-440. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201600491BibTex
@article{Schuller2017-03-02Activ-37503,
year={2017},
doi={10.1002/cbic.201600491},
title={Activation of the glmS Ribozyme Confers Bacterial Growth Inhibition},
number={5},
volume={18},
issn={1439-4227},
journal={ChemBioChem},
pages={435--440},
author={Schüller, Anna and Matzner, Daniel and Lünse, Christina E. and Wittmann, Valentin and Schumacher, Catherine and Unsleber, Sandra and Brötz-Oesterhelt, Heike and Mayer, Christoph and Bierbaum, Gabriele and Mayer, Günter}
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<dcterms:abstract xml:lang="eng">The ever-growing number of pathogenic bacteria resistant to treatment with antibiotics call for the development of novel compounds with as-yet unexplored modes of action. Here, we demonstrate the in vivo antibacterial activity of carba-α-d-glucosamine (CGlcN). In this mode of action study, we provide evidence that CGlcN-mediated growth inhibition is due to glmS ribozyme activation, and we demonstrate that CGlcN hijacks an endogenous activation pathway, hence utilizing a prodrug mechanism. This is the first report describing antibacterial activity mediated by activating the self-cleaving properties of a ribozyme. Our results open the path towards a compound class with an entirely novel and distinct molecular mechanism.</dcterms:abstract>
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