Publikation: Clinical update on cancer : molecular oncology of head and neck cancer
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2014
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Core Facility der Universität Konstanz
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Published
Erschienen in
Cell death & disease. Nature Publishing Group. 2014, 5, e1018. eISSN 2041-4889. Available under: doi: 10.1038/cddis.2013.548
Zusammenfassung
Head and neck cancers encompass a heterogeneous group of tumours that, in general, are biologically aggressive in nature. These cancers remain difficult to treat and treatment can cause severe, long-term side effects. For patients who are not cured by surgery and/or (chemo)radiotherapy, there are few effective treatment options. Targeted therapies and predictive biomarkers are urgently needed in order to improve the management and minimise the treatment toxicity, and to allow selection of patients who are likely to benefit from both nonselective and targeted therapies. This clinical update aims to provide an insight into the current understanding of the molecular pathogenesis of the disease, and explores the novel therapies under development and in clinical trials.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
head and neck squamous cell carcinoma, targeted therapy, HPV, metabolism, hypoxia, biomarkers
Konferenz
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ISO 690
SUH, Yae-Eun, Ivano AMELIO, Teresa GUERRERO URBANO, Mahvash TAVASSOLI, 2014. Clinical update on cancer : molecular oncology of head and neck cancer. In: Cell death & disease. Nature Publishing Group. 2014, 5, e1018. eISSN 2041-4889. Available under: doi: 10.1038/cddis.2013.548BibTex
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year={2014},
doi={10.1038/cddis.2013.548},
title={Clinical update on cancer : molecular oncology of head and neck cancer},
volume={5},
journal={Cell death & disease},
author={Suh, Yae-Eun and Amelio, Ivano and Guerrero Urbano, Teresa and Tavassoli, Mahvash},
note={Article Number: e1018}
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<dcterms:abstract xml:lang="eng">Head and neck cancers encompass a heterogeneous group of tumours that, in general, are biologically aggressive in nature. These cancers remain difficult to treat and treatment can cause severe, long-term side effects. For patients who are not cured by surgery and/or (chemo)radiotherapy, there are few effective treatment options. Targeted therapies and predictive biomarkers are urgently needed in order to improve the management and minimise the treatment toxicity, and to allow selection of patients who are likely to benefit from both nonselective and targeted therapies. This clinical update aims to provide an insight into the current understanding of the molecular pathogenesis of the disease, and explores the novel therapies under development and in clinical trials.</dcterms:abstract>
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