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Super-resolution microscopy of the immunological synapse

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2013

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Pageon, Sophie V.
Davis, Daniel M.
Gaus, Katharina

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https://doi.org/10.1016/j.coi.2013.04.002
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Current Opinion in Immunology. 2013, 25(3), pp. 307-312. ISSN 0952-7915. eISSN 1879-0372. Available under: doi: 10.1016/j.coi.2013.04.002

Zusammenfassung

Deciphering the spatial organisation of signalling proteins is the key to understanding the mechanisms underlying immune cell activation. Every advance in imaging technology has led to major breakthroughs in unravelling how receptor and signalling proteins are distributed within the plasma membrane and how membrane signalling is integrated with endosomes and vesicular trafficking. Recently, super-resolution fluorescence microscopy has been applied to immunological synapses, gaining new insights into the nanoscale organisation of signalling processes. Here, we review the advantages and potential of super-resolution microscopy for elucidating the regulation of many aspects of immune signalling.

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570 Biowissenschaften, Biologie

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ISO 690ROSSY, Jérémie, Sophie V. PAGEON, Daniel M. DAVIS, Katharina GAUS, 2013. Super-resolution microscopy of the immunological synapse. In: Current Opinion in Immunology. 2013, 25(3), pp. 307-312. ISSN 0952-7915. eISSN 1879-0372. Available under: doi: 10.1016/j.coi.2013.04.002
BibTex
@article{Rossy2013-06Super-43351,
  year={2013},
  doi={10.1016/j.coi.2013.04.002},
  title={Super-resolution microscopy of the immunological synapse},
  number={3},
  volume={25},
  issn={0952-7915},
  journal={Current Opinion in Immunology},
  pages={307--312},
  author={Rossy, Jérémie and Pageon, Sophie V. and Davis, Daniel M. and Gaus, Katharina}
}
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