Publikation: A novel stress-based intervention reduces cigarette use in non-treatment seeking smokers
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Tobacco use is the leading cause of preventable mortality worldwide. Since current smoking cessation aids show only modest efficacy, new interventions are needed. Given the evidence that stress is a potent trigger for smoking, the present randomized clinical trial tested whether stress could augment the effects of a memory updating (retrieval-extinction) intervention. Non-treatment seeking smokers (n = 76) were assigned to one of four conditions composed of either a stressful or non-stressful psychosocial challenge followed by either smoking or neutral cues. Ten minutes after this manipulation, all underwent a 60-minute extinction procedure during which they viewed smoking-related videos and images and manipulated smoking paraphernalia. Compared to participants who were not exposed to the laboratory stressor, the stressor-exposed groups exhibited greater psychophysiological responses during their intervention and greater decreases in cigarette use at two- and six-weeks follow-up independent of smoking cue exposure. Together, these findings suggest that the ability of stress to activate cigarette seeking processes can be exploited to decrease cigarette use. With replication, the stress-based intervention could become a novel strategy for decreasing cigarette use in non-treatment seeking smokers.Clinicaltrials.gov identifier: NCT04843969.
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BARNABE, Alexandra, Karine GAMACHE, João Vitor Paes DE CAMARGO, Erin ALLEN-FLANAGAN, Mathilde RIOUX, Jens C. PRUESSNER, Marco LEYTON, Karim NADER, 2023. A novel stress-based intervention reduces cigarette use in non-treatment seeking smokers. In: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. Springer Nature. 2023, 48, pp. 308-316. ISSN 0893-133X. eISSN 1740-634X. Available under: doi: 10.1038/s41386-022-01455-6BibTex
@article{Barnabe2023-03-29novel-58741, year={2023}, doi={10.1038/s41386-022-01455-6}, title={A novel stress-based intervention reduces cigarette use in non-treatment seeking smokers}, volume={48}, issn={0893-133X}, journal={Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology}, pages={308--316}, author={Barnabe, Alexandra and Gamache, Karine and de Camargo, João Vitor Paes and Allen-Flanagan, Erin and Rioux, Mathilde and Pruessner, Jens C. and Leyton, Marco and Nader, Karim} }
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