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Phospholipase C gamma 1 regulates early secretory trafficking and cell migration via interaction with p115

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2015

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Boncompain, Gaelle
Perez, Franck
Sztul, Elizabeth

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https://doi.org/10.1091/mbc.E15-03-0178
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Molecular Biology of the Cell. 2015, 26(12), pp. 2263-2278. ISSN 1044-2030. eISSN 1939-4586. Available under: doi: 10.1091/mbc.E15-03-0178

Zusammenfassung

The role of early secretory trafficking in the regulation of cell motility remains incompletely understood. Here, we used a siRNA screen monitoring effects on structure of the Golgi apparatus and on cell migration. Two major Golgi phenotypes were observed, fragmented and small Golgi. The latter exhibited a stronger correlation with a defect in cell migration. Among the small Golgi hits, we focused on phospholipase C gamma1 (PLCγ1). We show that PLCγ1 regulates Golgi structure and cell migration independently from its catalytic activity, but in a manner dependent on interaction with the tethering protein p115. PLCγ1 regulates the dynamics of p115 in the early secretory pathway, thereby controling trafficking from the endoplasmic reticulum to the Golgi. Our results uncover a new function of PLCγ1 that is independent of its catalytic function and link early secretory trafficking to the regulation of cell migration.

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570 Biowissenschaften, Biologie

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ISO 690MILLARTE, Valentina, Gaelle BONCOMPAIN, Kerstin D. TILLMANN, Franck PEREZ, Elizabeth SZTUL, Hesso FARHAN, 2015. Phospholipase C gamma 1 regulates early secretory trafficking and cell migration via interaction with p115. In: Molecular Biology of the Cell. 2015, 26(12), pp. 2263-2278. ISSN 1044-2030. eISSN 1939-4586. Available under: doi: 10.1091/mbc.E15-03-0178
BibTex
@article{Millarte2015Phosp-31683,
  year={2015},
  doi={10.1091/mbc.E15-03-0178},
  title={Phospholipase C gamma 1 regulates early secretory trafficking and cell migration via interaction with p115},
  number={12},
  volume={26},
  issn={1044-2030},
  journal={Molecular Biology of the Cell},
  pages={2263--2278},
  author={Millarte, Valentina and Boncompain, Gaelle and Tillmann, Kerstin D. and Perez, Franck and Sztul, Elizabeth and Farhan, Hesso}
}
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