Publikation: Mechanism of hypoglycaemic action of methylenecyclopropylglycine
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The effects of methylenecyclopropylglycine (MCPG), the lower homologue of hypoglycin A, on starved rats are described. Upon oral ingestion of MCPG (43 mg/kg), a 50% decrease in blood glucose compared with controls was observed after 4 h. The plasma concentrations of lactate and non-esterified fatty acids were substantially increased during this period. The activity of general acyl-CoA dehydrogenase from isolated rat liver mitochondria was not significantly changed. By contrast, the activity of 2-methyl-(branched-chain)-acyl-CoA dehydrogenase decreased by over 80%. The enzyme activity of enoyl-CoA hydratase (crotonase) from pig kidneys decreased by 80% on incubation with the hypothetically toxic metabolite of MCPG, methylenecyclopropylformyl-CoA. These results suggest that the inhibition spectrum of MCPG is quite different from that of hypoglycin A and that similar physiological effects might result from inhibition of different enzymes of β-oxidation, e.g. hypoglycaemia and lacticacidemia. Accumulation of medium-chain acyl-CoA thioesters is probably at the origin of disturbances in pyruvate metabolism.
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MELDE, Klaus, Hermann BUETTNER, Wolfgang BOSCHERT, Horst P. O. WOLF, Sandro GHISLA, 1989. Mechanism of hypoglycaemic action of methylenecyclopropylglycine. In: Biochemical Journal. 1989, 259(3), pp. 921-924. ISSN 0264-6021. eISSN 1470-8728. Available under: doi: 10.1042/bj2590921BibTex
@article{Melde1989Mecha-7877, year={1989}, doi={10.1042/bj2590921}, title={Mechanism of hypoglycaemic action of methylenecyclopropylglycine}, number={3}, volume={259}, issn={0264-6021}, journal={Biochemical Journal}, pages={921--924}, author={Melde, Klaus and Buettner, Hermann and Boschert, Wolfgang and Wolf, Horst P. O. and Ghisla, Sandro} }
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