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On the length distribution in bundles of polymerizing and depolymerizing actin filaments

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2010

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Schmeiser, Christian
Sfakianakis, Nikolaos

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Zusammenfassung

A model for the dynamics of the length distribution in polymer bundles is presented. It considers nucleation, polymerization, and depolymerization and is derived as a continuous macroscopic limit from a discrete description. Its main feature is a nonlinear coupling due to competition of the depolymerizing ends for the limited supply of a depolymerization agent. The model takes the form of an initial-boundary value problem for a one-dimensional nonlinear hyperbolic conservation law, subject to a nonlinear, nonlocal boundary condition. Besides existence and uniqueness of entropy solutions, convergence to a steady state is proven. Technical difficulties are caused by he fact that the prescribed boundary data are not always assumed by entropy solutions.

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Fachgebiet (DDC)
510 Mathematik

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Mathematische Biologie, Bewegung von Zellen, Mathematical Biology

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ISO 690FREISTÜHLER, Heinrich, Christian SCHMEISER, Nikolaos SFAKIANAKIS, 2010. On the length distribution in bundles of polymerizing and depolymerizing actin filaments
BibTex
@unpublished{Freistuhler2010lengt-697,
  year={2010},
  title={On the length distribution in bundles of polymerizing and depolymerizing actin filaments},
  author={Freistühler, Heinrich and Schmeiser, Christian and Sfakianakis, Nikolaos}
}
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