Publikation: Multiscale Metabolic Modeling : Dynamic Flux Balance Analysis on a Whole-Plant Scale
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Plant metabolism is characterized by a unique complexity on the cellular, tissue, and organ levels. On a whole-plant scale, changing source and sink relations accompanying plant development add another level of complexity to metabolism. With the aim of achieving a spatiotemporal resolution of source-sink interactions in crop plant metabolism, a multiscale metabolic modeling (MMM) approach was applied that integrates static organ-specific models with a whole-plant dynamic model. Allowing for a dynamic flux balance analysis on a whole-plant scale, the MMM approach was used to decipher the metabolic behavior of source and sink organs during the generative phase of the barley (Hordeum vulgare) plant. It reveals a sink-to-source shift of the barley stem caused by the senescence-related decrease in leaf source capacity, which is not sufficient to meet the nutrient requirements of sink organs such as the growing seed. The MMM platform represents a novel approach for the in silico analysis of metabolism on a whole-plant level, allowing for a systemic, spatiotemporally resolved understanding of metabolic processes involved in carbon partitioning, thus providing a novel tool for studying yield stability and crop improvement.
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GRAFAHREND-BELAU, E., A. JUNKER, André ESCHENRODER, Johannes MULLER, Falk SCHREIBER, B. H. JUNKER, 2013. Multiscale Metabolic Modeling : Dynamic Flux Balance Analysis on a Whole-Plant Scale. In: Plant Physiology. 2013, 163(2), pp. 637-647. ISSN 0032-0889. eISSN 1532-2548. Available under: doi: 10.1104/pp.113.224006BibTex
@article{GrafahrendBelau2013-10-08Multi-38287,
year={2013},
doi={10.1104/pp.113.224006},
title={Multiscale Metabolic Modeling : Dynamic Flux Balance Analysis on a Whole-Plant Scale},
number={2},
volume={163},
issn={0032-0889},
journal={Plant Physiology},
pages={637--647},
author={Grafahrend-Belau, E. and Junker, A. and Eschenroder, André and Muller, Johannes and Schreiber, Falk and Junker, B. H.}
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