Publikation:

Tunicamycin potently inhibits tumor necrosis factor-induced hepatocyte apoptosis

Lade...
Vorschaubild

Dateien

Leist_M_Eur_J_pharmacol_1995.pdf
Leist_M_Eur_J_pharmacol_1995.pdfGröße: 468.54 KBDownloads: 359

Datum

1995

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

ArXiv-ID

Internationale Patentnummer

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung
Open Access Green
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

European Journal of Pharmacology: Environmental Toxicology and Pharmacology Section. 1995, 292(2), pp. 201-204. ISSN 0926-6917. Available under: doi: 10.1016/0926-6917(95)90013-6

Zusammenfassung

The protein glycosylation inhibitor tunicamycin protected male BALB/c mice from tumor necrosis factor α-induced liver failure. Tunicamycin also inhibited tumor necrosis factor-induced cell death in primary hepatocyte cultures with a median inhibitory concentration of 8 nM, but not in the tumor cell line WEHI 164 clone 13. Hepatocyte death in our culture system was characterized by DNA fragmentation and apoptotic changes. These two characteristic signs of programmed cell death were also inhibited by tunicamycin treatment. These data suggest that protein glycosylation is an early and causal event of tumor necrosis factor (TNF)-induced parenchymal cell death in the liver.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Septic liver failure, Glycosylation inhibitor, Liver, mouse, DNA fragmentation

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690LEIST, Marcel, Albrecht WENDEL, 1995. Tunicamycin potently inhibits tumor necrosis factor-induced hepatocyte apoptosis. In: European Journal of Pharmacology: Environmental Toxicology and Pharmacology Section. 1995, 292(2), pp. 201-204. ISSN 0926-6917. Available under: doi: 10.1016/0926-6917(95)90013-6
BibTex
@article{Leist1995Tunic-7699,
  year={1995},
  doi={10.1016/0926-6917(95)90013-6},
  title={Tunicamycin potently inhibits tumor necrosis factor-induced hepatocyte apoptosis},
  number={2},
  volume={292},
  issn={0926-6917},
  journal={European Journal of Pharmacology: Environmental Toxicology and Pharmacology Section},
  pages={201--204},
  author={Leist, Marcel and Wendel, Albrecht}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/7699">
    <dc:creator>Wendel, Albrecht</dc:creator>
    <dc:format>application/pdf</dc:format>
    <dc:language>eng</dc:language>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dcterms:bibliographicCitation>First publ. in: European Journal of Pharmacology: Environmental Toxicology and Pharmacology Section 292 (1995), 2, pp. 201-204</dcterms:bibliographicCitation>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7699/1/Leist_M_Eur_J_pharmacol_1995.pdf"/>
    <dcterms:abstract xml:lang="eng">The protein glycosylation inhibitor tunicamycin protected male BALB/c mice from tumor necrosis factor α-induced liver failure. Tunicamycin also inhibited tumor necrosis factor-induced cell death in primary hepatocyte cultures with a median inhibitory concentration of 8 nM, but not in the tumor cell line WEHI 164 clone 13. Hepatocyte death in our culture system was characterized by DNA fragmentation and apoptotic changes. These two characteristic signs of programmed cell death were also inhibited by tunicamycin treatment. These data suggest that protein glycosylation is an early and causal event of tumor necrosis factor (TNF)-induced parenchymal cell death in the liver.</dcterms:abstract>
    <dc:contributor>Wendel, Albrecht</dc:contributor>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7699"/>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:36:28Z</dcterms:available>
    <dcterms:title>Tunicamycin potently inhibits tumor necrosis factor-induced hepatocyte apoptosis</dcterms:title>
    <dc:creator>Leist, Marcel</dc:creator>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:36:28Z</dc:date>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7699/1/Leist_M_Eur_J_pharmacol_1995.pdf"/>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:contributor>Leist, Marcel</dc:contributor>
    <dcterms:issued>1995</dcterms:issued>
    <dc:rights>terms-of-use</dc:rights>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
Begutachtet
Diese Publikation teilen