Linking membrane microdomains to the cytoskeleton : regulation of the lateral mobility of reggie-1/flotillin-2 by interaction with actin

Kurzanzeige
dc.contributor.authorLanghorst, Matthias F.deu
dc.contributor.authorSolis Padilla, Gonzalo
dc.contributor.authorHannbeck, Sylviadeu
dc.contributor.authorPlattner, Helmut
dc.contributor.authorStürmer, Claudia
dc.date.accessioned2011-03-23T09:06:27Zdeu
dc.date.available2011-03-23T09:06:27Zdeu
dc.date.issued2007-10-02
dc.description.abstractThe reggies/flotillins are oligomeric scaffolding proteins for membrane microdomains. We show here that reggie-1/flotillin-2 microdomains are organized along cortical F-actin in several cell types. Interaction with F-actin is mediated by the SPFH domain as shown by in vivo co-localization and in vitro binding experiments. Reggie-1/flotillin-2 microdomains form independent of actin, but disruption or stabilization of the actin cytoskeleton modulate the lateral mobility of reggie-1/flotillin-2 as shown by FRAP. Furthermore, reggie/flotillin microdomains can efficiently be immobilized by actin polymerisation, while exchange of reggie-1/flotillin-2 molecules between microdomains is enhanced by actin disruption as shown by tracking of individual microdomains using TIRF microscopy.eng
dc.description.versionpublished
dc.identifier.citationPubl. in: FEBS Letters ; 581 (2007), 24. - S. 4697-4703deu
dc.identifier.doi10.1016/j.febslet.2007.08.066eng
dc.identifier.pmid17850797
dc.identifier.ppn365752673deu
dc.identifier.urihttp://kops.uni-konstanz.de/handle/123456789/1146
dc.language.isoengdeu
dc.legacy.dateIssued2010deu
dc.rightsterms-of-usedeu
dc.rights.urihttps://rightsstatements.org/page/InC/1.0/deu
dc.subjectReggie/flotillindeu
dc.subjectActindeu
dc.subjectMembrane cytoskeletondeu
dc.subjectMembrane microdomaindeu
dc.subject.ddc570deu
dc.titleLinking membrane microdomains to the cytoskeleton : regulation of the lateral mobility of reggie-1/flotillin-2 by interaction with actineng
dc.typeJOURNAL_ARTICLEdeu
dspace.entity.typePublication
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@article{Langhorst2007-10-02Linki-1146,
  year={2007},
  doi={10.1016/j.febslet.2007.08.066},
  title={Linking membrane microdomains to the cytoskeleton : regulation of the lateral mobility of reggie-1/flotillin-2 by interaction with actin},
  number={24},
  volume={581},
  issn={0014-5793},
  journal={FEBS Letters},
  pages={4704--4710},
  author={Langhorst, Matthias F. and Solis Padilla, Gonzalo and Hannbeck, Sylvia and Plattner, Helmut and Stürmer, Claudia}
}
kops.citation.iso690LANGHORST, Matthias F., Gonzalo SOLIS PADILLA, Sylvia HANNBECK, Helmut PLATTNER, Claudia STÜRMER, 2007. Linking membrane microdomains to the cytoskeleton : regulation of the lateral mobility of reggie-1/flotillin-2 by interaction with actin. In: FEBS Letters. 2007, 581(24), pp. 4704-4710. ISSN 0014-5793. Available under: doi: 10.1016/j.febslet.2007.08.066deu
kops.citation.iso690LANGHORST, Matthias F., Gonzalo SOLIS PADILLA, Sylvia HANNBECK, Helmut PLATTNER, Claudia STÜRMER, 2007. Linking membrane microdomains to the cytoskeleton : regulation of the lateral mobility of reggie-1/flotillin-2 by interaction with actin. In: FEBS Letters. 2007, 581(24), pp. 4704-4710. ISSN 0014-5793. Available under: doi: 10.1016/j.febslet.2007.08.066eng
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