Publikation:

Linking membrane microdomains to the cytoskeleton : regulation of the lateral mobility of reggie-1/flotillin-2 by interaction with actin

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Datum

2007

Autor:innen

Langhorst, Matthias F.
Hannbeck, Sylvia

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http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-119206
DOI (zitierfähiger Link)
https://doi.org/10.1016/j.febslet.2007.08.066
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Published

Erschienen in

FEBS Letters. 2007, 581(24), pp. 4704-4710. ISSN 0014-5793. Available under: doi: 10.1016/j.febslet.2007.08.066

Zusammenfassung

The reggies/flotillins are oligomeric scaffolding proteins for membrane microdomains. We show here that reggie-1/flotillin-2 microdomains are organized along cortical F-actin in several cell types. Interaction with F-actin is mediated by the SPFH domain as shown by in vivo co-localization and in vitro binding experiments. Reggie-1/flotillin-2 microdomains form independent of actin, but disruption or stabilization of the actin cytoskeleton modulate the lateral mobility of reggie-1/flotillin-2 as shown by FRAP. Furthermore, reggie/flotillin microdomains can efficiently be immobilized by actin polymerisation, while exchange of reggie-1/flotillin-2 molecules between microdomains is enhanced by actin disruption as shown by tracking of individual microdomains using TIRF microscopy.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Reggie/flotillin, Actin, Membrane cytoskeleton, Membrane microdomain

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ISO 690LANGHORST, Matthias F., Gonzalo SOLIS PADILLA, Sylvia HANNBECK, Helmut PLATTNER, Claudia STÜRMER, 2007. Linking membrane microdomains to the cytoskeleton : regulation of the lateral mobility of reggie-1/flotillin-2 by interaction with actin. In: FEBS Letters. 2007, 581(24), pp. 4704-4710. ISSN 0014-5793. Available under: doi: 10.1016/j.febslet.2007.08.066
BibTex
@article{Langhorst2007-10-02Linki-1146,
  year={2007},
  doi={10.1016/j.febslet.2007.08.066},
  title={Linking membrane microdomains to the cytoskeleton : regulation of the lateral mobility of reggie-1/flotillin-2 by interaction with actin},
  number={24},
  volume={581},
  issn={0014-5793},
  journal={FEBS Letters},
  pages={4704--4710},
  author={Langhorst, Matthias F. and Solis Padilla, Gonzalo and Hannbeck, Sylvia and Plattner, Helmut and Stürmer, Claudia}
}
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