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Targeting Kidney Fibrosis with Polymeric Nanocarriers

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Datum

2024

Autor:innen

Kulkarni, Vedangi
Caspers, Tim
Moeckel, Diana
Koletnik, Susanne
Rama, Elena
Pola, Robert
Klinkhammer, Barbara M.
Lammers, Twan
et al.

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Institutionen der Bundesrepublik Deutschland: STOP-FSGS-01GM2202C
European Union (EU): 101001791
European Union (EU): 864121
Deutsche Forschungsgemeinschaft (DFG): 322900939
Deutsche Forschungsgemeinschaft (DFG): 432698239
Deutsche Forschungsgemeinschaft (DFG): 445703531
European Union (EU): 955879

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Core Facility der Universität Konstanz

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Chemistry of Materials. ACS Publications. 2024, 36(19), S. 9686-9695. ISSN 0897-4756. eISSN 1520-5002. Verfügbar unter: doi: 10.1021/acs.chemmater.4c01788

Zusammenfassung

Chronic kidney disease (CKD) presents a significant health challenge, affecting nearly 10% of the global population. The management of CKD is hampered by the lack of drugs and drug delivery systems that specifically target the pathways, cells, and compartments involved in driving disease progression. We therefore set out to study the kidney targeting potential of polymeric nanocarriers based on poly(N-(2-hydroxypropyl)methacrylamide) (p(HPMA)) in mice with unilateral ischemia-reperfusion-induced kidney fibrosis. Multimodal and multiscale optical imaging was employed to assess the kidney accumulation of six dye-labeled polymers differing in size and charge (7 and 32 kDa; neutral, negative, and positive) upon intravenous and subcutaneous administration. Particularly, the negatively charged 32 kDa polymeric nanocarrier was found to target diseased kidneys effectively, having a fibrosis-to-healthy kidney accumulation ratio of 4.0 ± 0.5 at 72 h post injection. Fluorescence microscopy showed that this polymer is predominantly retained within renal tubular cells. These findings unlock the potential of exploring p(HPMA)-based polymeric nanocarriers for kidney-targeted drug delivery and CKD treatment.

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Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Conjugated polymers, Fluorescence, Polymers, Rodent models, Targeting

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ISO 690KULKARNI, Vedangi, Tim CASPERS, Diana MOECKEL, Susanne KOLETNIK, Elena RAMA, Paraskevi SOTIROPOULOU, Daniel R. DIETRICH, Robert POLA, Barbara M. KLINKHAMMER, Twan LAMMERS, 2024. Targeting Kidney Fibrosis with Polymeric Nanocarriers. In: Chemistry of Materials. ACS Publications. 2024, 36(19), S. 9686-9695. ISSN 0897-4756. eISSN 1520-5002. Verfügbar unter: doi: 10.1021/acs.chemmater.4c01788
BibTex
@article{Kulkarni2024-10-08Targe-71185,
  year={2024},
  doi={10.1021/acs.chemmater.4c01788},
  title={Targeting Kidney Fibrosis with Polymeric Nanocarriers},
  number={19},
  volume={36},
  issn={0897-4756},
  journal={Chemistry of Materials},
  pages={9686--9695},
  author={Kulkarni, Vedangi and Caspers, Tim and Moeckel, Diana and Koletnik, Susanne and Rama, Elena and Sotiropoulou, Paraskevi and Dietrich, Daniel R. and Pola, Robert and Klinkhammer, Barbara M. and Lammers, Twan}
}
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