@article{Jonghe2011-01-01Synth-19906,
  year={2011},
  doi={10.1016/j.bmcl.2010.11.053},
  title={Synthesis and in vitro evaluation of 2-amino-4-N-piperazinyl-6-(3,4-dimethoxyphenyl)-pteridines as dual immunosuppressive and anti-inflammatory agents},
  number={1},
  volume={21},
  issn={0960-894X},
  journal={Bioorganic & Medicinal Chemistry Letters},
  pages={145--149},
  author={Jonghe, Steven De and Marchand, Arnaud and Gao, Ling-Jie and Calleja, Agnes and Cuveliers, Eva and Sienaert, Ilse and Herman, Jean and Clydesdale, Gavin and Sefrioui, Hassane and Lin, Yuan and Pfleiderer, Wolfgang and Waer, Mark and Herdewijn, Piet}
}

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    <dcterms:bibliographicCitation>Publ. in: Bioorganic &amp; medicinal chemistry letters ; 21 (2011), 1. - pp. 145-149</dcterms:bibliographicCitation>
    <dc:contributor>Calleja, Agnes</dc:contributor>
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    <dcterms:abstract xml:lang="eng">Screening of a pteridine-based compound library led to the identification of compounds exhibiting immunosuppressive as well as anti-inflammatory activity. Optimization afforded a series of 2-amino-4-N-piperazinyl-6-(3,4-dimethoxyphenyl)pteridine analogues. The most potent congeners in this series displayed low nM IC50 values in the Mixed Lymphocyte Reaction (MLR) assay. In addition, these compounds also have potent anti-inflammatory activity as measured in the Tumor Necrosis Factor (TNF) assay.</dcterms:abstract>
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    <dcterms:title>Synthesis and in vitro evaluation of 2-amino-4-N-piperazinyl-6-(3,4-dimethoxyphenyl)-pteridines as dual immunosuppressive and anti-inflammatory agents</dcterms:title>
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    <dc:contributor>Herman, Jean</dc:contributor>
    <dc:contributor>Gao, Ling-Jie</dc:contributor>
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    <dc:contributor>Herdewijn, Piet</dc:contributor>
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    <dc:contributor>Marchand, Arnaud</dc:contributor>
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    <dc:creator>Waer, Mark</dc:creator>
    <dc:creator>Lin, Yuan</dc:creator>
    <dc:creator>Marchand, Arnaud</dc:creator>
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    <dc:contributor>Cuveliers, Eva</dc:contributor>
    <dc:contributor>Pfleiderer, Wolfgang</dc:contributor>
    <dc:contributor>Jonghe, Steven De</dc:contributor>
    <dc:contributor>Clydesdale, Gavin</dc:contributor>
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