Publikation: Age, sex and BMI influence on copper, zinc and their major serum carrier proteins in a large European population including Nonagenarian Offspring from MARK-AGE study
Dateien
Datum
Autor:innen
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
DOI (zitierfähiger Link)
Internationale Patentnummer
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Sammlungen
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Publikationsstatus
Erschienen in
Zusammenfassung
The analysis of copper (Cu) and zinc (Zn) along with their major serum carriers, albumin (Alb) and ceruloplasmin (Cp), could provide information on the capacity of humans to maintain homeostasis of metals (metallostasis). However, their relationship with aging, sex, BMI, as well as with nutritional and inflammatory markers was never investigated in a large-scale study. Here, we report results from the European large-scale cross-sectional study MARK-AGE in which Cu, Zn, Alb, Cp as well as nutritional and inflammatory parameters were determined in 2424 age-stratified subjects (35-75 years) including the general population (RASIG), nonagenarian offspring (GO), a well-studied genetic model of longevity, and spouses of GO (SGO). In RASIG, Cu to Zn ratio and Cp to Alb ratio were higher in women than in men. Both ratios increased with aging because Cu and Cp increased and Alb and Zn decreased. Cu, Zn, Alb and Cp were found associated with several inflammatory as well as nutritional biomarkers.GO showed higher Zn levels and higher Zn to Alb ratio compared to RASIG, but we did not observe significant differences with SGO, likely as a consequence of the low sample size of SGO and the shared environment. Our results show that aging, sex, BMI and GO status are characterized by different levels of Cu, Zn and their serum carrier proteins. These data and their relationship with inflammatory biomarkers support the concept that loss of metallostasis is a characteristic of inflammaging.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
Schlagwörter
Konferenz
Rezension
Zitieren
ISO 690
PIACENZA, Francesco, Robertina GIACCONI, Laura COSTARELLI, Andrea BASSO, Alexander BÜRKLE, Maria MORENO-VILLANUEVA, Martijn E T DOLLÉ, Eugène JANSEN, Tilman GRUNE, Marco MALAVOLTA, 2021. Age, sex and BMI influence on copper, zinc and their major serum carrier proteins in a large European population including Nonagenarian Offspring from MARK-AGE study. In: The journals of gerontology. Series A, Biological sciences and medical sciences. Oxford Academic. 2021, 76(12), pp. 2097-2106. eISSN 1758-535X. Available under: doi: 10.1093/gerona/glab134BibTex
@article{Piacenza2021-11-15influ-53726, year={2021}, doi={10.1093/gerona/glab134}, title={Age, sex and BMI influence on copper, zinc and their major serum carrier proteins in a large European population including Nonagenarian Offspring from MARK-AGE study}, number={12}, volume={76}, journal={The journals of gerontology. Series A, Biological sciences and medical sciences}, pages={2097--2106}, author={Piacenza, Francesco and Giacconi, Robertina and Costarelli, Laura and Basso, Andrea and Bürkle, Alexander and Moreno-Villanueva, Maria and Dollé, Martijn E T and Jansen, Eugène and Grune, Tilman and Malavolta, Marco} }
RDF
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/53726"> <dc:contributor>Bürkle, Alexander</dc:contributor> <dc:creator>Costarelli, Laura</dc:creator> <dc:contributor>Malavolta, Marco</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-05-20T09:23:55Z</dc:date> <dc:creator>Giacconi, Robertina</dc:creator> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/53726"/> <dc:contributor>Piacenza, Francesco</dc:contributor> <dc:contributor>Costarelli, Laura</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-05-20T09:23:55Z</dcterms:available> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <dc:creator>Dollé, Martijn E T</dc:creator> <dcterms:title>Age, sex and BMI influence on copper, zinc and their major serum carrier proteins in a large European population including Nonagenarian Offspring from MARK-AGE study</dcterms:title> <dc:creator>Grune, Tilman</dc:creator> <dcterms:abstract xml:lang="eng">The analysis of copper (Cu) and zinc (Zn) along with their major serum carriers, albumin (Alb) and ceruloplasmin (Cp), could provide information on the capacity of humans to maintain homeostasis of metals (metallostasis). However, their relationship with aging, sex, BMI, as well as with nutritional and inflammatory markers was never investigated in a large-scale study. Here, we report results from the European large-scale cross-sectional study MARK-AGE in which Cu, Zn, Alb, Cp as well as nutritional and inflammatory parameters were determined in 2424 age-stratified subjects (35-75 years) including the general population (RASIG), nonagenarian offspring (GO), a well-studied genetic model of longevity, and spouses of GO (SGO). In RASIG, Cu to Zn ratio and Cp to Alb ratio were higher in women than in men. Both ratios increased with aging because Cu and Cp increased and Alb and Zn decreased. Cu, Zn, Alb and Cp were found associated with several inflammatory as well as nutritional biomarkers.GO showed higher Zn levels and higher Zn to Alb ratio compared to RASIG, but we did not observe significant differences with SGO, likely as a consequence of the low sample size of SGO and the shared environment. Our results show that aging, sex, BMI and GO status are characterized by different levels of Cu, Zn and their serum carrier proteins. These data and their relationship with inflammatory biomarkers support the concept that loss of metallostasis is a characteristic of inflammaging.</dcterms:abstract> <dcterms:issued>2021-11-15</dcterms:issued> <dc:creator>Moreno-Villanueva, Maria</dc:creator> <dc:creator>Piacenza, Francesco</dc:creator> <dc:contributor>Dollé, Martijn E T</dc:contributor> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Grune, Tilman</dc:contributor> <dc:creator>Malavolta, Marco</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dc:creator>Basso, Andrea</dc:creator> <dc:creator>Jansen, Eugène</dc:creator> <dc:rights>terms-of-use</dc:rights> <dc:language>eng</dc:language> <dc:creator>Bürkle, Alexander</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dc:contributor>Basso, Andrea</dc:contributor> <dc:contributor>Giacconi, Robertina</dc:contributor> <dc:contributor>Jansen, Eugène</dc:contributor> <dc:contributor>Moreno-Villanueva, Maria</dc:contributor> </rdf:Description> </rdf:RDF>