@article{Heck2017-03-27Exome-41290,
  year={2017},
  doi={10.1038/s41562-017-0081},
  title={Exome sequencing of healthy phenotypic extremes links TROVE2 to emotional memory and PTSD},
  number={4},
  volume={1},
  journal={Nature Human Behaviour},
  author={Heck, Angela and Milnik, Annette and Vukojevic, Vanja and Petrovska, Jana and Egli, Tobias and Singer, Jochen and Escobar, Pablo and Kolassa, Iris-Tatjana and Elbert, Thomas and Papassotiropoulos, Andreas},
  note={Article Number: 0081}
}

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    <dc:contributor>Petrovska, Jana</dc:contributor>
    <dc:contributor>Milnik, Annette</dc:contributor>
    <dc:contributor>Papassotiropoulos, Andreas</dc:contributor>
    <dcterms:issued>2017-03-27</dcterms:issued>
    <dc:contributor>Escobar, Pablo</dc:contributor>
    <dc:contributor>Elbert, Thomas</dc:contributor>
    <dc:creator>Singer, Jochen</dc:creator>
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    <dc:creator>Petrovska, Jana</dc:creator>
    <dcterms:abstract xml:lang="eng">Many mental disorders represent the extremes of the normal distribution of traits, which are related to multiple cognitive and emotional dimensions. By performing whole-exome sequencing of healthy, young subjects with extremely high versus extremely low aversive memory performance, we identified TROVE2 as a gene implicated in emotional memory in health and disease. TROVE2 encodes Ro60, a broadly expressed RNA-binding protein implicated in the regulation of inflammatory gene expression and autoimmunity. A regulatory TROVE2 variant was linked to higher emotional memory capacity and higher emotional memory-related brain activation in healthy subjects. In addition, TROVE2 was associated with traumatic memory and the frequency of post-traumatic stress disorder in genocide survivors.</dcterms:abstract>
    <dc:creator>Milnik, Annette</dc:creator>
    <dc:creator>Elbert, Thomas</dc:creator>
    <dc:creator>Papassotiropoulos, Andreas</dc:creator>
    <dc:creator>Kolassa, Iris-Tatjana</dc:creator>
    <dc:contributor>Heck, Angela</dc:contributor>
    <dc:contributor>Vukojevic, Vanja</dc:contributor>
    <dc:creator>Heck, Angela</dc:creator>
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    <dc:contributor>Singer, Jochen</dc:contributor>
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    <dcterms:title>Exome sequencing of healthy phenotypic extremes links TROVE2 to emotional memory and PTSD</dcterms:title>
    <dc:contributor>Egli, Tobias</dc:contributor>
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    <dc:creator>Egli, Tobias</dc:creator>
    <dc:creator>Vukojevic, Vanja</dc:creator>
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