Exome sequencing of healthy phenotypic extremes links TROVE2 to emotional memory and PTSD

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2017
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Heck, Angela
Milnik, Annette
Vukojevic, Vanja
Petrovska, Jana
Egli, Tobias
Singer, Jochen
Escobar, Pablo
Papassotiropoulos, Andreas
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Zusammenfassung

Many mental disorders represent the extremes of the normal distribution of traits, which are related to multiple cognitive and emotional dimensions. By performing whole-exome sequencing of healthy, young subjects with extremely high versus extremely low aversive memory performance, we identified TROVE2 as a gene implicated in emotional memory in health and disease. TROVE2 encodes Ro60, a broadly expressed RNA-binding protein implicated in the regulation of inflammatory gene expression and autoimmunity. A regulatory TROVE2 variant was linked to higher emotional memory capacity and higher emotional memory-related brain activation in healthy subjects. In addition, TROVE2 was associated with traumatic memory and the frequency of post-traumatic stress disorder in genocide survivors.

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ISO 690HECK, Angela, Annette MILNIK, Vanja VUKOJEVIC, Jana PETROVSKA, Tobias EGLI, Jochen SINGER, Pablo ESCOBAR, Iris-Tatjana KOLASSA, Thomas ELBERT, Andreas PAPASSOTIROPOULOS, 2017. Exome sequencing of healthy phenotypic extremes links TROVE2 to emotional memory and PTSD. In: Nature Human Behaviour. 2017, 1(4), 0081. eISSN 2397-3374. Available under: doi: 10.1038/s41562-017-0081
BibTex
@article{Heck2017-03-27Exome-41290,
  year={2017},
  doi={10.1038/s41562-017-0081},
  title={Exome sequencing of healthy phenotypic extremes links TROVE2 to emotional memory and PTSD},
  number={4},
  volume={1},
  journal={Nature Human Behaviour},
  author={Heck, Angela and Milnik, Annette and Vukojevic, Vanja and Petrovska, Jana and Egli, Tobias and Singer, Jochen and Escobar, Pablo and Kolassa, Iris-Tatjana and Elbert, Thomas and Papassotiropoulos, Andreas},
  note={Article Number: 0081}
}
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