Publikation:

Reconfiguration of DNA methylation in aging

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Datum

2015

Autor:innen

Zampieri, Michele
Ciccarone, Fabio
Calabrese, Roberta
Franceschi, Claudio
Caiafa, Paola

Herausgeber:innen

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URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-0-312460
DOI (zitierfähiger Link)
https://doi.org/10.1016/j.mad.2015.02.002
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CC BY-NC-ND 4.0

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Open Access-Veröffentlichung
Open Access Hybrid

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Biologie: Publikationen
Core Facility der Universität Konstanz

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Titel in einer weiteren Sprache

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Zeitschriftenartikel
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Published

Erschienen in

Mechanisms of Ageing and Development. 2015, 151, pp. 60-70. ISSN 0047-6374. eISSN 1872-6216. Available under: doi: 10.1016/j.mad.2015.02.002

Zusammenfassung

A complex interplay between multiple biological effects shapes the aging process. The advent of genome-wide quantitative approaches in the epigenetic field has highlighted the effective impact of epigenetic deregulation, particularly of DNA methylation, on aging. Age-associated alterations in DNA methylation are commonly grouped in the phenomenon known as "epigenetic drift" which is characterized by gradual extensive demethylation of genome and hypermethylation of a number of promoter-associated CpG islands. Surprisingly, specific DNA regions show directional epigenetic changes in aged individuals suggesting the importance of these events for the aging process. However, the epigenetic information obtained until now in aging needs a re-consideration due to the recent discovery of 5-hydroxymethylcytosine, a new DNA epigenetic mark present on genome. A recapitulation of the factors involved in the regulation of DNA methylation and the changes occurring in aging will be described in this review also considering the data available on 5hmC.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

DNA methylation, Aging, Epigenetic reprogramming, 5-Methylcytosine, 5-Hydroxymethylcytosine

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ISO 690ZAMPIERI, Michele, Fabio CICCARONE, Roberta CALABRESE, Claudio FRANCESCHI, Alexander BÜRKLE, Paola CAIAFA, 2015. Reconfiguration of DNA methylation in aging. In: Mechanisms of Ageing and Development. 2015, 151, pp. 60-70. ISSN 0047-6374. eISSN 1872-6216. Available under: doi: 10.1016/j.mad.2015.02.002
BibTex
@article{Zampieri2015Recon-33335,
  year={2015},
  doi={10.1016/j.mad.2015.02.002},
  title={Reconfiguration of DNA methylation in aging},
  volume={151},
  issn={0047-6374},
  journal={Mechanisms of Ageing and Development},
  pages={60--70},
  author={Zampieri, Michele and Ciccarone, Fabio and Calabrese, Roberta and Franceschi, Claudio and Bürkle, Alexander and Caiafa, Paola}
}
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