An evolutionary balance : conservation vs innovation in ciliate membrane trafficking

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2017
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Guerrier, S.
Richardson, Elisabeth
Dacks, Joel B.
Turkewitz, Aaron P.
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Traffic. 2017, 18(1), pp. 18-28. ISSN 1398-9219. eISSN 1600-0854. Available under: doi: 10.1111/tra.12450
Zusammenfassung

As most of eukaryotic diversity lies in single-celled protists, they represent unique opportunities to ask questions about the balance of conservation and innovation in cell biological features. Among free-living protists the ciliates offer ease of culturing, a rich array of experimental approaches, and versatile molecular tools, particularly in Tetrahymena thermophila and Paramecium tetraurelia. These attributes have been exploited by researchers to analyze a wealth of cellular structures in these large and complex cells. This mini-review focuses on three aspects of ciliate membrane dynamics, all linked with endolysosomal trafficking. First is nutrition based on phagocytosis and maturation of food vacuoles. Secondly, we discuss regulated exocytosis from vesicles that have features of both dense core secretory granules but also lysosome-related organelles. The third topic is the targeting, breakdown and resorption of parental nuclei in mating partners. For all three phenomena, it is clear that elements of the canonical membrane-trafficking system have been retained and in some cases repurposed. In addition, there is evidence that recently evolved, lineage-specific proteins provide determinants in these pathways.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Alevolate, Rab GTPase, Snare, autophagy, calcium signaling, nucleophagy, vesicles
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ISO 690GUERRIER, S., Helmut PLATTNER, Elisabeth RICHARDSON, Joel B. DACKS, Aaron P. TURKEWITZ, 2017. An evolutionary balance : conservation vs innovation in ciliate membrane trafficking. In: Traffic. 2017, 18(1), pp. 18-28. ISSN 1398-9219. eISSN 1600-0854. Available under: doi: 10.1111/tra.12450
BibTex
@article{Guerrier2017evolu-37983,
  year={2017},
  doi={10.1111/tra.12450},
  title={An evolutionary balance : conservation vs innovation in ciliate membrane trafficking},
  number={1},
  volume={18},
  issn={1398-9219},
  journal={Traffic},
  pages={18--28},
  author={Guerrier, S. and Plattner, Helmut and Richardson, Elisabeth and Dacks, Joel B. and Turkewitz, Aaron P.}
}
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