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A single residue exchange within a viral CTL epitope alters proteasome-mediated degradation resulting in lack of antigen presentation

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1996

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Ossendorp, Ferry
Eggers, Maren
Neisig, Anne
Ruppert, Thomas
Sijts, Alice
Mengedé, Erica
Kloetzel, Peter-Michael
Neefjes, Jacques
Koszinowski, Ulrich

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Immunity. 1996, 5(2), pp. 115-124. ISSN 1074-7613. eISSN 1097-4180. Available under: doi: 10.1016/S1074-7613(00)80488-4

Zusammenfassung

CTL epitope (KSPWFTTL) encoded by AKV/MCF type of murine leukemia virus (MuLV) differs from the sequence in Friend/Moloney/Rauscher (FMR) type in one residue (RSPWFTTL). CTL experiments indicated defective processing of the FMR peptide in tumor cells. Proteasome-mediated digestion of AKV/MCF-type 26-mer peptides resulted in the early generation and higher levels of epitope-containing fragments than digestion of FMR-type peptides, explained by prominent cleavage next to R in the FMR sequence. The fragments were identified as 10- and 11-mer peptides and were efficiently translocated by TAP. The naturally presented AKV/MCF peptide is the 8-mer, indicating ER peptide trimming. In conclusion, a single residue exchange can cause CTL epitope destruction by specific proteasomal cleavage.

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570 Biowissenschaften, Biologie

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ISO 690OSSENDORP, Ferry, Maren EGGERS, Anne NEISIG, Thomas RUPPERT, Marcus GRÖTTRUP, Alice SIJTS, Erica MENGEDÉ, Peter-Michael KLOETZEL, Jacques NEEFJES, Ulrich KOSZINOWSKI, Cornelis MELIEF, 1996. A single residue exchange within a viral CTL epitope alters proteasome-mediated degradation resulting in lack of antigen presentation. In: Immunity. 1996, 5(2), pp. 115-124. ISSN 1074-7613. eISSN 1097-4180. Available under: doi: 10.1016/S1074-7613(00)80488-4
BibTex
@article{Ossendorp1996singl-22317,
  year={1996},
  doi={10.1016/S1074-7613(00)80488-4},
  title={A single residue exchange within a viral CTL epitope alters proteasome-mediated degradation resulting in lack of antigen presentation},
  number={2},
  volume={5},
  issn={1074-7613},
  journal={Immunity},
  pages={115--124},
  author={Ossendorp, Ferry and Eggers, Maren and Neisig, Anne and Ruppert, Thomas and Gröttrup, Marcus and Sijts, Alice and Mengedé, Erica and Kloetzel, Peter-Michael and Neefjes, Jacques and Koszinowski, Ulrich and Melief, Cornelis}
}
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    <dcterms:abstract xml:lang="eng">CTL epitope (KSPWFTTL) encoded by AKV/MCF type of murine leukemia virus (MuLV) differs from the sequence in Friend/Moloney/Rauscher (FMR) type in one residue (RSPWFTTL). CTL experiments indicated defective processing of the FMR peptide in tumor cells. Proteasome-mediated digestion of AKV/MCF-type 26-mer peptides resulted in the early generation and higher levels of epitope-containing fragments than digestion of FMR-type peptides, explained by prominent cleavage next to R in the FMR sequence. The fragments were identified as 10- and 11-mer peptides and were efficiently translocated by TAP. The naturally presented AKV/MCF peptide is the 8-mer, indicating ER peptide trimming. In conclusion, a single residue exchange can cause CTL epitope destruction by specific proteasomal cleavage.</dcterms:abstract>
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