A Test of the Neutral Model of Expression Change in Natural Populations of House Mouse Subspecies

Vorschaubild nicht verfügbar
Dateien
Zu diesem Dokument gibt es keine Dateien.
Datum
2010
Autor:innen
Staubach, Fabian
Teschke, Meike
Wolf, Jochen B. W.
Tautz, Diethard
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
eISSN
item.preview.dc.identifier.isbn
Bibliografische Daten
Verlag
Schriftenreihe
URI (zitierfähiger Link)
DOI (zitierfähiger Link)
ArXiv-ID
Internationale Patentnummer
Link zur Lizenz
oops
EU-Projektnummer
Projekt
Open Access-Veröffentlichung
Sammlungen
Gesperrt bis
Titel in einer weiteren Sprache
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
Evolution ; 64 (2010), 2. - S. 549-560. - Oxford University Press. - ISSN 0014-3820. - eISSN 1558-5646
Zusammenfassung
Changes in expression of genes are thought to contribute significantly to evolutionary divergence. To study the relative role of selection and neutrality in shaping expression changes, we analyzed 24 genes in three different tissues of the house mouse (Mus musculus). Samples from two natural populations of the subspecies M. m. domesticus and M. m. musculus were investigated using quantitative PCR assays and sequencing of the upstream region. We have developed an approach to quantify expression polymorphism within such populations and to disentangle technical from biological variation in the data. We found a correlation between expression polymorphism within populations and divergence between populations. Furthermore, we found a correlation between expression polymorphism and sequence polymorphism of the respective genes. These data are most easily interpreted within a framework of a predominantly neutral model of gene expression change, where only a fraction of the changes may have been driven by positive selection. Although most genes investigated were expressed in all three tissues analyzed, significant changes of expression levels occurred predominantly in a single tissue only. This adds to the notion that enhancer‐specific effects or transregulatory effects can modulate the evolution of gene expression in a tissue‐specific way.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Konferenz
Rezension
undefined / . - undefined, undefined. - (undefined; undefined)
Zitieren
ISO 690STAUBACH, Fabian, Meike TESCHKE, Christian R. VOOLSTRA, Jochen B. W. WOLF, Diethard TAUTZ, 2010. A Test of the Neutral Model of Expression Change in Natural Populations of House Mouse Subspecies. In: Evolution. Oxford University Press. 64(2), pp. 549-560. ISSN 0014-3820. eISSN 1558-5646. Available under: doi: 10.1111/j.1558-5646.2009.00818.x
BibTex
@article{Staubach2010Neutr-66455,
  year={2010},
  doi={10.1111/j.1558-5646.2009.00818.x},
  title={A Test of the Neutral Model of Expression Change in Natural Populations of House Mouse Subspecies},
  number={2},
  volume={64},
  issn={0014-3820},
  journal={Evolution},
  pages={549--560},
  author={Staubach, Fabian and Teschke, Meike and Voolstra, Christian R. and Wolf, Jochen B. W. and Tautz, Diethard}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/66455">
    <dc:contributor>Staubach, Fabian</dc:contributor>
    <dc:contributor>Teschke, Meike</dc:contributor>
    <dc:contributor>Tautz, Diethard</dc:contributor>
    <dcterms:abstract>Changes in expression of genes are thought to contribute significantly to evolutionary divergence. To study the relative role of selection and neutrality in shaping expression changes, we analyzed 24 genes in three different tissues of the house mouse (Mus musculus). Samples from two natural populations of the subspecies M. m. domesticus and M. m. musculus were investigated using quantitative PCR assays and sequencing of the upstream region. We have developed an approach to quantify expression polymorphism within such populations and to disentangle technical from biological variation in the data. We found a correlation between expression polymorphism within populations and divergence between populations. Furthermore, we found a correlation between expression polymorphism and sequence polymorphism of the respective genes. These data are most easily interpreted within a framework of a predominantly neutral model of gene expression change, where only a fraction of the changes may have been driven by positive selection. Although most genes investigated were expressed in all three tissues analyzed, significant changes of expression levels occurred predominantly in a single tissue only. This adds to the notion that enhancer‐specific effects or transregulatory effects can modulate the evolution of gene expression in a tissue‐specific way.</dcterms:abstract>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2023-03-24T08:06:58Z</dc:date>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/66455"/>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:contributor>Wolf, Jochen B. W.</dc:contributor>
    <dc:contributor>Voolstra, Christian R.</dc:contributor>
    <dcterms:issued>2010</dcterms:issued>
    <dc:creator>Teschke, Meike</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:creator>Staubach, Fabian</dc:creator>
    <dc:language>eng</dc:language>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2023-03-24T08:06:58Z</dcterms:available>
    <dcterms:title>A Test of the Neutral Model of Expression Change in Natural Populations of House Mouse Subspecies</dcterms:title>
    <dc:creator>Voolstra, Christian R.</dc:creator>
    <dc:creator>Tautz, Diethard</dc:creator>
    <dc:creator>Wolf, Jochen B. W.</dc:creator>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
  </rdf:Description>
</rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Kontakt
URL der Originalveröffentl.
Prüfdatum der URL
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Begutachtet
Ja