Publikation:

Causal Inference Approaches Reveal Associations Between LDL Oxidation, NO Metabolism, Telomere Length and DNA Integrity Within the MARK-AGE Study

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2025

Autor:innen

Valeanu, Andrei
Margina, Denisa
Blasco, María
Sikora, Ewa
Mosieniak, Grazyna
Capri, Miriam
Breusing, Nicolle
Gradinaru, Daniela
et al.

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http://nbn-resolving.de/urn:nbn:de:bsz:352-2-1eb67ikgx0r8m2
DOI (zitierfähiger Link)
https://doi.org/10.3390/antiox14080933
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CC BY 4.0

Angaben zur Forschungsförderung

European Union (EU): 200880

Projekt

MARK-AGE: European study to establish biomarkers of human ageing
Open Access-Veröffentlichung
Open Access Gold

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Biologie: Publikationen
Sportwissenschaft: Publikationen
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Published

Erschienen in

Antioxidants. MDPI. 2025, 14(8), 933. eISSN 2076-3921. Verfügbar unter: doi: 10.3390/antiox14080933

Zusammenfassung

Genomic instability markers are important hallmarks of aging, as previously evidenced within the European study of biomarkers of human aging, MARK-AGE; however, establishing the specific metabolic determinants of vascular aging is challenging. The objective of the present study was to evaluate the impact of the susceptibility to oxidation of serum LDL particles (LDLox) and the plasma metabolization products of nitric oxide (NOx) on relevant genomic instability markers. The analysis was performed on a MARK-AGE cohort of 1326 subjects (635 men and 691 women, 35–75 years old) randomly recruited from the general population. The Inverse Probability of Treatment Weighting causal inference algorithm was implemented in order to assess the potential causal relationship between the LDLox and NOx octile-based thresholds and three genomic instability markers measured in mononuclear leukocytes: the percentage of telomeres shorter than 3 kb, the initial DNA integrity, and the DNA damage after irradiation with 3.8 Gy. The results showed statistically significant telomere shortening for LDLox, while NOx yielded a significant impact on DNA integrity. Overall, the effect on the genomic instability markers was higher than for the confirmed vascular aging determinants, such as low HDL cholesterol levels, indicating a meaningful impact even for small changes in LDLox and NOx values.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

genomic instability markers, LDL oxidation, nitric oxide, causal analysis, MARK-AGE, vascular aging

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ISO 690VALEANU, Andrei, Denisa MARGINA, Maria MORENO-VILLANUEVA, María BLASCO, Ewa SIKORA, Grazyna MOSIENIAK, Miriam CAPRI, Nicolle BREUSING, Alexander BÜRKLE, Daniela GRADINARU, 2025. Causal Inference Approaches Reveal Associations Between LDL Oxidation, NO Metabolism, Telomere Length and DNA Integrity Within the MARK-AGE Study. In: Antioxidants. MDPI. 2025, 14(8), 933. eISSN 2076-3921. Verfügbar unter: doi: 10.3390/antiox14080933
BibTex
@article{Valeanu2025-07-30Causa-74938,
  title={Causal Inference Approaches Reveal Associations Between LDL Oxidation, NO Metabolism, Telomere Length and DNA Integrity Within the MARK-AGE Study},
  year={2025},
  doi={10.3390/antiox14080933},
  number={8},
  volume={14},
  journal={Antioxidants},
  author={Valeanu, Andrei and Margina, Denisa and Moreno-Villanueva, Maria and Blasco, María and Sikora, Ewa and Mosieniak, Grazyna and Capri, Miriam and Breusing, Nicolle and Bürkle, Alexander and Gradinaru, Daniela},
  note={Article Number: 933}
}
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