Publikation:

Liquid biopsies and cancer omics

Lade...
Vorschaubild

Dateien

Amelio_2-1dyn4edgryqfc7.pdf
Amelio_2-1dyn4edgryqfc7.pdfGröße: 1.17 MBDownloads: 61

Datum

2020

Autor:innen

Bertolo, Riccardo
Bove, Pierluigi
Buonomo, Oreste Claudio
Candi, Eleonora
Chiocchi, Marcello
Cipriani, Chiara
Di Daniele, Nicola
Ganini, Carlo
Melino, Gerry
et al.

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

ArXiv-ID

Internationale Patentnummer

Link zur Lizenz

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung
Open Access Gold
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Cell Death Discovery. Nature Publishing Group. 2020, 6(1), 131. eISSN 2058-7716. Available under: doi: 10.1038/s41420-020-00373-0

Zusammenfassung

The development of the sequencing technologies allowed the generation of huge amounts of molecular data from a single cancer specimen, allowing the clinical oncology to enter the era of the precision medicine. This massive amount of data is highlighting new details on cancer pathogenesis but still relies on tissue biopsies, which are unable to capture the dynamic nature of cancer through its evolution. This assumption led to the exploration of non-tissue sources of tumoral material opening the field of liquid biopsies. Blood, together with body fluids such as urines, or stool, from cancer patients, are analyzed applying the techniques used for the generation of omics data. With blood, this approach would allow to take into account tumor heterogeneity (since the circulating components such as CTCs, ctDNA, or ECVs derive from each cancer clone) in a time dependent manner, resulting in a somehow "real-time" understanding of cancer evolution. Liquid biopsies are beginning nowdays to be applied in many cancer contexts and are at the basis of many clinical trials in oncology.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690AMELIO, Ivano, Riccardo BERTOLO, Pierluigi BOVE, Oreste Claudio BUONOMO, Eleonora CANDI, Marcello CHIOCCHI, Chiara CIPRIANI, Nicola DI DANIELE, Carlo GANINI, Gerry MELINO, 2020. Liquid biopsies and cancer omics. In: Cell Death Discovery. Nature Publishing Group. 2020, 6(1), 131. eISSN 2058-7716. Available under: doi: 10.1038/s41420-020-00373-0
BibTex
@article{Amelio2020-11-26Liqui-57058,
  year={2020},
  doi={10.1038/s41420-020-00373-0},
  title={Liquid biopsies and cancer omics},
  number={1},
  volume={6},
  journal={Cell Death Discovery},
  author={Amelio, Ivano and Bertolo, Riccardo and Bove, Pierluigi and Buonomo, Oreste Claudio and Candi, Eleonora and Chiocchi, Marcello and Cipriani, Chiara and Di Daniele, Nicola and Ganini, Carlo and Melino, Gerry},
  note={Article Number: 131}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/57058">
    <dc:creator>Melino, Gerry</dc:creator>
    <dc:contributor>Chiocchi, Marcello</dc:contributor>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dcterms:title>Liquid biopsies and cancer omics</dcterms:title>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/57058/3/Amelio_2-1dyn4edgryqfc7.pdf"/>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dcterms:abstract xml:lang="eng">The development of the sequencing technologies allowed the generation of huge amounts of molecular data from a single cancer specimen, allowing the clinical oncology to enter the era of the precision medicine. This massive amount of data is highlighting new details on cancer pathogenesis but still relies on tissue biopsies, which are unable to capture the dynamic nature of cancer through its evolution. This assumption led to the exploration of non-tissue sources of tumoral material opening the field of liquid biopsies. Blood, together with body fluids such as urines, or stool, from cancer patients, are analyzed applying the techniques used for the generation of omics data. With blood, this approach would allow to take into account tumor heterogeneity (since the circulating components such as CTCs, ctDNA, or ECVs derive from each cancer clone) in a time dependent manner, resulting in a somehow "real-time" understanding of cancer evolution. Liquid biopsies are beginning nowdays to be applied in many cancer contexts and are at the basis of many clinical trials in oncology.</dcterms:abstract>
    <dc:language>eng</dc:language>
    <dc:creator>Bertolo, Riccardo</dc:creator>
    <dc:contributor>Cipriani, Chiara</dc:contributor>
    <dc:creator>Cipriani, Chiara</dc:creator>
    <dc:contributor>Bove, Pierluigi</dc:contributor>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-03-30T07:06:17Z</dcterms:available>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:creator>Di Daniele, Nicola</dc:creator>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/57058/3/Amelio_2-1dyn4edgryqfc7.pdf"/>
    <dc:contributor>Bertolo, Riccardo</dc:contributor>
    <dc:contributor>Amelio, Ivano</dc:contributor>
    <dc:contributor>Candi, Eleonora</dc:contributor>
    <dc:rights>Attribution 4.0 International</dc:rights>
    <dc:creator>Amelio, Ivano</dc:creator>
    <dc:contributor>Di Daniele, Nicola</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-03-30T07:06:17Z</dc:date>
    <dc:creator>Bove, Pierluigi</dc:creator>
    <dc:creator>Candi, Eleonora</dc:creator>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/57058"/>
    <dcterms:issued>2020-11-26</dcterms:issued>
    <dc:creator>Ganini, Carlo</dc:creator>
    <dc:contributor>Melino, Gerry</dc:contributor>
    <dc:creator>Chiocchi, Marcello</dc:creator>
    <dc:creator>Buonomo, Oreste Claudio</dc:creator>
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/4.0/"/>
    <dc:contributor>Ganini, Carlo</dc:contributor>
    <dc:contributor>Buonomo, Oreste Claudio</dc:contributor>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
Begutachtet
Unbekannt
Diese Publikation teilen