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A sustainable one-pot method to transform seashell waste calcium carbonate to osteoinductive hydroxyapatite micro-nanoparticles

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2023

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Fernández-Penas, Raquel
Verdugo-Escamilla, Cristóbal
Triunfo, Carla
D'Urso, Annarita
Oltolina, Francesca
Follenzi, Antonia
Maoloni, Gabriele
Gómez-Morales, Jaime
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European Union (EU): 817992
European Union (EU): 817992

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Journal of Materials Chemistry B : Materials for Biology and Medicine. Royal Society of Chemistry (RSC). 2023, 11(32), pp. 7766-7777. ISSN 2050-750X. eISSN 2050-7518. Available under: doi: 10.1039/d3tb00856h

Zusammenfassung

We have developed a straightforward, one-pot, low-temperature hydrothermal method to transform oyster shell waste particles (bCCP) from the species Crassostrea gigas (Mg-calcite, 5 wt% Mg) into hydroxyapatite (HA) micro/nanoparticles. The influence of the P reagents (H3PO4, KH2PO4, and K2HPO4), P/bCCP molar ratios (0.24, 0.6, and 0.96), digestion temperatures (25–200 °C), and digestion times (1 week–2 months) on the transformation process was thoroughly investigated. At 1 week, the minimum temperature to yield the full transformation significantly reduced from 160 °C to 120 °C when using K2HPO4 instead of KH2PO4 at a P/bCCP ratio of 0.6, and even to 80 °C at a P/bCCP ratio of 0.96. The transformation took place via a dissolution–reprecipitation mechanism driven by the favorable balance between HA precipitation and bCCP dissolution, due to the lower solubility product of HA than that of calcite at any of the tested temperatures. Both the bCCP and the derived HA particles were cytocompatible for MG-63 human osteosarcoma cells and m17.ASC murine mesenchymal stem cells, and additionally, they promoted the osteogenic differentiation of m17.ASC, especially the HA particles. Because of their physicochemical features and biological compatibility, both particles could be useful osteoinductive platforms for translational applications in bone tissue engineering.

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540 Chemie

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General Materials Science

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ISO 690FERNÁNDEZ-PENAS, Raquel, Cristóbal VERDUGO-ESCAMILLA, Carla TRIUNFO, Stefanie GÄRTNER, Annarita D'URSO, Francesca OLTOLINA, Antonia FOLLENZI, Gabriele MAOLONI, Helmut CÖLFEN, Jaime GÓMEZ-MORALES, 2023. A sustainable one-pot method to transform seashell waste calcium carbonate to osteoinductive hydroxyapatite micro-nanoparticles. In: Journal of Materials Chemistry B : Materials for Biology and Medicine. Royal Society of Chemistry (RSC). 2023, 11(32), pp. 7766-7777. ISSN 2050-750X. eISSN 2050-7518. Available under: doi: 10.1039/d3tb00856h
BibTex
@article{FernandezPenas2023susta-67490,
  year={2023},
  doi={10.1039/d3tb00856h},
  title={A sustainable one-pot method to transform seashell waste calcium carbonate to osteoinductive hydroxyapatite micro-nanoparticles},
  number={32},
  volume={11},
  issn={2050-750X},
  journal={Journal of Materials Chemistry B : Materials for Biology and Medicine},
  pages={7766--7777},
  author={Fernández-Penas, Raquel and Verdugo-Escamilla, Cristóbal and Triunfo, Carla and Gärtner, Stefanie and D'Urso, Annarita and Oltolina, Francesca and Follenzi, Antonia and Maoloni, Gabriele and Cölfen, Helmut and Gómez-Morales, Jaime}
}
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