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Cyclohexane-1,2-dione hydrolase : A new tool to degrade alicyclic compounds

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2009

Autor:innen

Steinbach, Alma K.
Tabbert, Anja
Harder, Jens
Ermler, Ulrich
Tittmann, Kai

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Journal of Molecular Catalysis / B, Enzymatic. 2009, 61(1-2), pp. 47-49. ISSN 1381-1177. Available under: doi: 10.1016/j.molcatb.2009.03.021

Zusammenfassung

Alicyclic alcohols are naturally occurring compounds which can be degraded by microorganisms via cleavage of the ring C-C bond. Denitrifying Azoarcus sp. strain 22Lin grows on cyclohexane-1,2-diol which serves as electron donor and carbon source. The diol is converted to cyclohexane-1,2-dione followed by hydrolysis to the corresponding semialdehyde and oxidation to adipate. The latter two reactions are catalyzed by the thiamine diphosphate-dependent llavoenzyme cyciohexane-1,2-dione hydrolase, the first α-ketolase known so far. Biochemical and structural properties of this new member of the thiamine diphosphate enzyme family will be presented.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
540 Chemie

Schlagwörter

Cyclic alcohols, Cyclohexane-1.2-dione hydrolase, Thiamine diphosphate, Flavoenzyme

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ISO 690FRAAS, Sonja Iris, Alma K. STEINBACH, Anja TABBERT, Jens HARDER, Ulrich ERMLER, Kai TITTMANN, Axel MEYER, Peter M. H. KRONECK, 2009. Cyclohexane-1,2-dione hydrolase : A new tool to degrade alicyclic compounds. In: Journal of Molecular Catalysis / B, Enzymatic. 2009, 61(1-2), pp. 47-49. ISSN 1381-1177. Available under: doi: 10.1016/j.molcatb.2009.03.021
BibTex
@article{Fraas2009Cyclo-9816,
  year={2009},
  doi={10.1016/j.molcatb.2009.03.021},
  title={Cyclohexane-1,2-dione hydrolase : A new tool to degrade alicyclic compounds},
  number={1-2},
  volume={61},
  issn={1381-1177},
  journal={Journal of Molecular Catalysis / B, Enzymatic},
  pages={47--49},
  author={Fraas, Sonja Iris and Steinbach, Alma K. and Tabbert, Anja and Harder, Jens and Ermler, Ulrich and Tittmann, Kai and Meyer, Axel and Kroneck, Peter M. H.}
}
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