Publikation: Mechanistic and functional diversity in the mechanosensory kinases of the titin-like family
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Biochemical Society Transactions. 2013, 41(4), pp. 1066-1071. ISSN 0300-5127. eISSN 1470-8752. Available under: doi: 10.1042/BST20130085
Zusammenfassung
The giant cytoskeletal kinases of the titin-like family are emerging as key mediators of stretch-sensing in muscle. It is thought that their elastic conformational deformation during muscle function regulates both their catalysis and the recruitment of regulatory proteins to signalosomes that assemble in their vicinity. In the present article, we discuss the speciation of mechanosensory mechanisms in titin-like kinases, their scaffolding properties and the kinase/pseudokinase domain variations that define a rich functional diversity across the family.
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570 Biowissenschaften, Biologie
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MAYANS, Olga, Guy M. BENIAN, Felix SIMKOVIC, Daniel J. RIGDEN, 2013. Mechanistic and functional diversity in the mechanosensory kinases of the titin-like family. In: Biochemical Society Transactions. 2013, 41(4), pp. 1066-1071. ISSN 0300-5127. eISSN 1470-8752. Available under: doi: 10.1042/BST20130085BibTex
@article{Mayans2013-08-01Mecha-34943,
year={2013},
doi={10.1042/BST20130085},
title={Mechanistic and functional diversity in the mechanosensory kinases of the titin-like family},
number={4},
volume={41},
issn={0300-5127},
journal={Biochemical Society Transactions},
pages={1066--1071},
author={Mayans, Olga and Benian, Guy M. and Simkovic, Felix and Rigden, Daniel J.}
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