Synthesis and X-ray structure analysis of a heptacoordinate titanium(IV)-bis-chelate with enhanced in vivo antitumor efficacy

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Chemical Communications. 2012, 48(46), pp. 5790-5792. ISSN 1359-7345. eISSN 1364-548X. Available under: doi: 10.1039/C2CC31624B
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Chelate stabilization of a titanium(IV)–salan alkoxide by ligand exchange with 2,6-pyridinedicarboxylic acid (dipic) resulted in heptacoordinate complex 3 which is not redox-active, stable on silica gel and has increased aqueous stability. 3 is highly toxic in HeLa S3 and Hep G2 and has enhanced antitumor efficacy in a mouse cervical-cancer model.

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ISO 690IMMEL, Timo, Martin GRÜTZKE, Anne-Katrin SPÄTE, Ulrich GROTH, Peter ÖHLSCHLÄGER, Thomas HUHN, 2012. Synthesis and X-ray structure analysis of a heptacoordinate titanium(IV)-bis-chelate with enhanced in vivo antitumor efficacy. In: Chemical Communications. 2012, 48(46), pp. 5790-5792. ISSN 1359-7345. eISSN 1364-548X. Available under: doi: 10.1039/C2CC31624B
BibTex
@article{Immel2012-06-11Synth-20133,
  year={2012},
  doi={10.1039/C2CC31624B},
  title={Synthesis and X-ray structure analysis of a heptacoordinate titanium(IV)-bis-chelate with enhanced in vivo antitumor efficacy},
  number={46},
  volume={48},
  issn={1359-7345},
  journal={Chemical Communications},
  pages={5790--5792},
  author={Immel, Timo and Grützke, Martin and Späte, Anne-Katrin and Groth, Ulrich and Öhlschläger, Peter and Huhn, Thomas}
}
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    <dcterms:abstract xml:lang="eng">Chelate stabilization of a titanium(IV)–salan alkoxide by ligand exchange with 2,6-pyridinedicarboxylic acid (dipic) resulted in heptacoordinate complex 3 which is not redox-active, stable on silica gel and has increased aqueous stability. 3 is highly toxic in HeLa S3 and Hep G2 and has enhanced antitumor efficacy in a mouse cervical-cancer model.</dcterms:abstract>
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