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Testing the Impact of Protease Inhibitors in Antigen Presentation Assays

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2019

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https://doi.org/10.1007/978-1-4939-9450-2_5
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ENDERT, Peter van, ed.. Antigen Processing : Methods and Protocols. second edition. New York, NY: Humana Press, 2019, pp. 59-69. Methods in Molecular Biology. 1988. ISBN 978-1-4939-9449-6. Available under: doi: 10.1007/978-1-4939-9450-2_5

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The major histocompatibility complex (MHC) class I restricted pathway of antigen processing allows the presentation of intracellular antigens to cytotoxic T lymphocytes. The proteasome is the main protease in the cytoplasm and the nucleus, which is responsible for the generation of most peptide ligands of MHC-I molecules. Peptides produced by the proteasome can be further trimmed or destroyed by numerous cytosolic or endoplasmic reticulum (ER) luminal proteases. Small molecule inhibitors are useful tools for probing the role of proteases in MHC class I antigen processing. Here, we describe different methods to test the impact of protease inhibitors in antigen presentation assays.

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570 Biowissenschaften, Biologie

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ISO 690BASLER, Michael, Marcus GRÖTTRUP, 2019. Testing the Impact of Protease Inhibitors in Antigen Presentation Assays. In: ENDERT, Peter van, ed.. Antigen Processing : Methods and Protocols. second edition. New York, NY: Humana Press, 2019, pp. 59-69. Methods in Molecular Biology. 1988. ISBN 978-1-4939-9449-6. Available under: doi: 10.1007/978-1-4939-9450-2_5
BibTex
@incollection{Basler2019Testi-45967,
  year={2019},
  doi={10.1007/978-1-4939-9450-2_5},
  title={Testing the Impact of Protease Inhibitors in Antigen Presentation Assays},
  edition={second edition},
  number={1988},
  isbn={978-1-4939-9449-6},
  publisher={Humana Press},
  address={New York, NY},
  series={Methods in Molecular Biology},
  booktitle={Antigen Processing : Methods and Protocols},
  pages={59--69},
  editor={Endert, Peter van},
  author={Basler, Michael and Gröttrup, Marcus}
}
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