Stability of auditory event-related potentials in coma research

Schorr, Barbara; Schlee, Winfried; Arndt, Marion; Lulé, Dorothée; Kolassa, Iris-Tatjana; Lopez-Rolon, Alexander; Bender, Andreas

Stability of auditory event-related potentials in coma research

Dateien

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Datum

2015

Autor:innen

Schorr, Barbara

Schlee, Winfried

Arndt, Marion

Lulé, Dorothée

Kolassa, Iris-Tatjana

Lopez-Rolon, Alexander

Bender, Andreas

DOI (zitierfähiger Link)

https://doi.org/10.1007/s00415-014-7561-y

Sammlungen

Psychologie
Biologie

Publikationstyp

Zeitschriftenartikel

unikn.publication.listelement.citation.prefix.version.undefined

Journal of Neurology. 2015, 262(2), pp. 307-315. ISSN 0340-5354. eISSN 1432-1459. Available under: doi: 10.1007/s00415-014-7561-y

Zusammenfassung

Patients with unresponsive wakefulness syndrome (UWS) or in minimally conscious state (MCS) after brain injury show significant fluctuations in their behavioural abilities over time. As the importance of event-related potentials (ERPs) in the detection of traces of consciousness increases, we investigated the retest reliability of ERPs with repeated tests at four different time points. Twelve healthy controls and 12 inpatients (8 UWS, 4 MCS; 6 traumatic, 6 non-traumatic) were tested twice a day (morning, afternoon) for 2 days with an auditory oddball task. ERPs were recorded with a 256-channel-EEG system, and correlated with behavioural test scores in the Coma Recovery Scale-revised (CRS-R). The number of identifiable P300 responses varied between zero and four in both groups. Reliabilities varied between Krippendorff's α = 0.43 for within-day comparison, and α = 0.25 for between-day comparison in the patient group. Retest reliability was strong for the CRS-R scores for all comparisons (α = 0.83-0.95). The stability of auditory information processing in patients with disorders of consciousness is the basis for other, even more demanding tasks and cognitive potentials. The relatively low ERP-retest reliability suggests that it is necessary to perform repeated tests, especially when probing for consciousness with ERPs. A single negative ERP test result may be mistaken for proof that a UWS patient truly is unresponsive.

Fachgebiet (DDC)

150 Psychologie

Schlagwörter

Disorders of consciousness , Minimally conscious state, Unresponsive wakefulness syndrome, P300, ERPs, EEG

Zitieren

ISO 690

SCHORR, Barbara, Winfried SCHLEE, Marion ARNDT, Dorothée LULÉ, Iris-Tatjana KOLASSA, Alexander LOPEZ-ROLON, Andreas BENDER, 2015. Stability of auditory event-related potentials in coma research. In: Journal of Neurology. 2015, 262(2), pp. 307-315. ISSN 0340-5354. eISSN 1432-1459. Available under: doi: 10.1007/s00415-014-7561-y

BibTex

@article{Schorr2015Stabi-29890,
  year={2015},
  doi={10.1007/s00415-014-7561-y},
  title={Stability of auditory event-related potentials in coma research},
  number={2},
  volume={262},
  issn={0340-5354},
  journal={Journal of Neurology},
  pages={307--315},
  author={Schorr, Barbara and Schlee, Winfried and Arndt, Marion and Lulé, Dorothée and Kolassa, Iris-Tatjana and Lopez-Rolon, Alexander and Bender, Andreas}
}

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