Publikation: Engineered DNA Polymerases in Biotechnology
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2010
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ChemBioChem. 2010, 11(15), pp. 2077-2084. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201000215
Zusammenfassung
DNA polymerases are the enzymes that catalyse all DNA synthesis in Nature often with astounding speed and accuracy. Consequently, their features as molecular machines are exploited in a wide range of biotechnological applications. Some features are highlighted in the following. For example, DNA polymerases are useful enzymes to detect genomic alterations that can lead to the development of certain diseases such as cancer or to promote toxic side effects of drugs. Methods for the detection of single-nucleotide polymorphisms, copy-number variations and somatic copy-number alterations are important for the realisation of personalised medicine.[1 3] Additionally, new DNA sequencing technologies aim to achieve the $ 1000 genome that might further drive a new era of specific pharmaceutical treatments and diseaseprevention strategies based on an individual s genome.[4 7] In many DNA diagnostic and sequencing methods, the accurate action of a DNA polymerase to incorporate the right nucleotide with high selectivity, according to the Watson Crick rule, is crucial.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
540 Chemie
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directed evolution, DNA polymerase, pathogen detection, polymerase chain reaction, sequencing
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KRANASTER, Ramon, Andreas MARX, 2010. Engineered DNA Polymerases in Biotechnology. In: ChemBioChem. 2010, 11(15), pp. 2077-2084. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201000215BibTex
@article{Kranaster2010Engin-9910,
year={2010},
doi={10.1002/cbic.201000215},
title={Engineered DNA Polymerases in Biotechnology},
number={15},
volume={11},
issn={1439-4227},
journal={ChemBioChem},
pages={2077--2084},
author={Kranaster, Ramon and Marx, Andreas}
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<dcterms:abstract xml:lang="eng">DNA polymerases are the enzymes that catalyse all DNA synthesis in Nature often with astounding speed and accuracy. Consequently, their features as molecular machines are exploited in a wide range of biotechnological applications. Some features are highlighted in the following. For example, DNA polymerases are useful enzymes to detect genomic alterations that can lead to the development of certain diseases such as cancer or to promote toxic side effects of drugs. Methods for the detection of single-nucleotide polymorphisms, copy-number variations and somatic copy-number alterations are important for the realisation of personalised medicine.[1 3] Additionally, new DNA sequencing technologies aim to achieve the $ 1000 genome that might further drive a new era of specific pharmaceutical treatments and diseaseprevention strategies based on an individual s genome.[4 7] In many DNA diagnostic and sequencing methods, the accurate action of a DNA polymerase to incorporate the right nucleotide with high selectivity, according to the Watson Crick rule, is crucial.</dcterms:abstract>
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