Publikation: Extra-adrenal glucocorticoid synthesis at epithelial barriers
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2019
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Genes and Immunity. 2019, 20(8), pp. 627-640. ISSN 1466-4879. eISSN 1476-5470. Available under: doi: 10.1038/s41435-019-0058-z
Zusammenfassung
Epithelial barriers play an important role in the exchange of nutrients, gases, and other signals between our body and the outside world. However, they protect it also from invasion by potential pathogens. Defective epithelial barriers and associated overshooting immune responses are the basis of many different inflammatory disorders of the skin, the lung, and the intestinal mucosa. The anti-inflammatory activity of glucocorticoids has been efficiently used for the treatment of these diseases. Interestingly, epithelia in these tissues are also a rich source of endogenous glucocorticoids, suggesting that local glucocorticoid synthesis is part of a tissue-specific regulatory circuit. In this review, we summarize current knowledge about the extra-adrenal glucocorticoid synthesis at the epithelial barriers of the intestine, lung and the skin, and discuss their relevance in the pathogenesis of inflammatory diseases and as therapeutic targets.
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570 Biowissenschaften, Biologie
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PHAN, Truong San, Verena M. MERK, Thomas BRUNNER, 2019. Extra-adrenal glucocorticoid synthesis at epithelial barriers. In: Genes and Immunity. 2019, 20(8), pp. 627-640. ISSN 1466-4879. eISSN 1476-5470. Available under: doi: 10.1038/s41435-019-0058-zBibTex
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title={Extra-adrenal glucocorticoid synthesis at epithelial barriers},
number={8},
volume={20},
issn={1466-4879},
journal={Genes and Immunity},
pages={627--640},
author={Phan, Truong San and Merk, Verena M. and Brunner, Thomas}
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<dcterms:abstract xml:lang="eng">Epithelial barriers play an important role in the exchange of nutrients, gases, and other signals between our body and the outside world. However, they protect it also from invasion by potential pathogens. Defective epithelial barriers and associated overshooting immune responses are the basis of many different inflammatory disorders of the skin, the lung, and the intestinal mucosa. The anti-inflammatory activity of glucocorticoids has been efficiently used for the treatment of these diseases. Interestingly, epithelia in these tissues are also a rich source of endogenous glucocorticoids, suggesting that local glucocorticoid synthesis is part of a tissue-specific regulatory circuit. In this review, we summarize current knowledge about the extra-adrenal glucocorticoid synthesis at the epithelial barriers of the intestine, lung and the skin, and discuss their relevance in the pathogenesis of inflammatory diseases and as therapeutic targets.</dcterms:abstract>
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