Abnormal resting-state cortical coupling in chronic Tinnitus

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1471_2202_10_11.pdf
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BMC Neuroscience. 2009, 10(1), 11. eISSN 1471-2202. Available under: doi: 10.1186/1471-2202-10-11
Zusammenfassung

Background:
Subjective tinnitus is characterized by an auditory phantom perception in the absence of any physical sound source. Consequently, in a quiet environment, tinnitus patients differ from control participants because they constantly perceive a sound whereas controls do not. We hypothesized that this difference is expressed by differential activation of distributed cortical networks.
Results:
The analysis was based on a sample of 41 participants: 21 patients with chronic tinnitus and 20 healthy control participants. To investigate the architecture of these networks, we used phase locking analysis in the 1 90 Hz frequency range of a minute of resting-state MEG recording. We found: 1) For tinnitus patients: A significant decrease of inter-areal coupling in the alpha (9 12 Hz) band and an increase of inter-areal coupling in the 48 54 Hz gamma frequency range relative to the control group. 2) For both groups: an inverse relationship (r = -.71) of the alpha and gamma network coupling. 3) A discrimination of 83% between the patient and the control group based on the alpha and gamma networks. 4) An effect of manifestation on the distribution of the gamma network: In patients with a tinnitus history of less than 4 years, the left temporal cortex was predominant in the gamma network whereas in patients with tinnitus duration of more than 4 years, the gamma network was more widely distributed including more frontal and parietal regions.
Conclusion:
In the here presented data set we found strong support for an alteration of long-range coupling in tinnitus. Long-range coupling in the alpha frequency band was decreased for tinnitus patients while long-range gamma coupling was increased. These changes discriminate well between tinnitus and control participants. We propose a tinnitus model that integrates this finding in the current knowledge about tinnitus. Furthermore we discuss the impact of this finding to tinnitus therapies using Transcranial Magnetic Stimulation (TMS).

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150 Psychologie
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ISO 690SCHLEE, Winfried, Thomas HARTMANN, Berthold LANGGUTH, Nathan WEISZ, 2009. Abnormal resting-state cortical coupling in chronic Tinnitus. In: BMC Neuroscience. 2009, 10(1), 11. eISSN 1471-2202. Available under: doi: 10.1186/1471-2202-10-11
BibTex
@article{Schlee2009Abnor-6481,
  year={2009},
  doi={10.1186/1471-2202-10-11},
  title={Abnormal resting-state cortical coupling in chronic Tinnitus},
  number={1},
  volume={10},
  journal={BMC Neuroscience},
  author={Schlee, Winfried and Hartmann, Thomas and Langguth, Berthold and Weisz, Nathan},
  note={Article Number: 11}
}
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