Publikation:

Transforming growth factor β1 inhibits Fas ligand expression and subsequent activation-induced cell death in T cells via down-regulation of c-Myc

Lade...
Vorschaubild

Dateien

1999_Genestier_Transforming Growth Factor.pdf
1999_Genestier_Transforming Growth Factor.pdfGröße: 282.52 KBDownloads: 223

Datum

1999

Autor:innen

Genestier, Laurent
Kasibhatla, Shailaja
Green, Douglas R.

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

ArXiv-ID

Internationale Patentnummer

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung
Open Access Green
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Journal of Experimental Medicine. 1999, 189(2), pp. 231-239. ISSN 0022-1007. Available under: doi: 10.1084/jem.189.2.231

Zusammenfassung

Activation-induced cell death (AICD) is a process that regulates the size and the duration of the primary immune T cell response. In this report, we investigated the mechanisms involved in the regulation of AICD by transforming growth factor b1 (TGFb1). We found that TGFb1 decreased apoptosis of human T cells or T cell hybridomas after activation by anti-CD3. This decrease was associated with inhibition of Fas (Apo-1/CD95) ligand (FasL) expression, whereas Fas signaling was not affected by TGFb1. In parallel, TGFb1 inhibited c-Myc expression in T cell hybridomas, and ectopic expression of a chimeric molecule composed of c-Myc and the steroid binding domain of the estrogen receptor (Myc-ER) blocked both the inhibition of FasL and the decrease of AICD induced by TGFb1, providing that 4-hydroxytamoxifen was present. These results identify one mechanism by which TGFb1 blocks AICD to allow the clonal expansion of effector T cells and the generation of memory T cells during immune responses.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690GENESTIER, Laurent, Shailaja KASIBHATLA, Thomas BRUNNER, Douglas R. GREEN, 1999. Transforming growth factor β1 inhibits Fas ligand expression and subsequent activation-induced cell death in T cells via down-regulation of c-Myc. In: Journal of Experimental Medicine. 1999, 189(2), pp. 231-239. ISSN 0022-1007. Available under: doi: 10.1084/jem.189.2.231
BibTex
@article{Genestier1999Trans-14303,
  year={1999},
  doi={10.1084/jem.189.2.231},
  title={Transforming growth factor β1 inhibits Fas ligand expression and subsequent activation-induced cell death in T cells via down-regulation of c-Myc},
  number={2},
  volume={189},
  issn={0022-1007},
  journal={Journal of Experimental Medicine},
  pages={231--239},
  author={Genestier, Laurent and Kasibhatla, Shailaja and Brunner, Thomas and Green, Douglas R.}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/14303">
    <dc:creator>Kasibhatla, Shailaja</dc:creator>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/14303/2/1999_Genestier_Transforming%20Growth%20Factor.pdf"/>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dcterms:bibliographicCitation>First publ. in: The Journal of Experimental Medicine ; 189 (1999), 2. - S. 231-239</dcterms:bibliographicCitation>
    <dc:contributor>Genestier, Laurent</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-10-24T12:49:11Z</dc:date>
    <dc:creator>Green, Douglas R.</dc:creator>
    <dcterms:title>Transforming growth factor β1 inhibits Fas ligand expression and subsequent activation-induced cell death in T cells via down-regulation of c-Myc</dcterms:title>
    <dc:creator>Genestier, Laurent</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:contributor>Brunner, Thomas</dc:contributor>
    <dc:contributor>Green, Douglas R.</dc:contributor>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/14303"/>
    <dcterms:abstract xml:lang="deu">Activation-induced cell death (AICD) is a process that regulates the size and the duration of the primary immune T cell response. In this report, we investigated the mechanisms involved in the regulation of AICD by transforming growth factor b1 (TGFb1). We found that TGFb1 decreased apoptosis of human T cells or T cell hybridomas after activation by anti-CD3. This decrease was associated with inhibition of Fas (Apo-1/CD95) ligand (FasL) expression, whereas Fas signaling was not affected by TGFb1. In parallel, TGFb1 inhibited c-Myc expression in T cell hybridomas, and ectopic expression of a chimeric molecule composed of c-Myc and the steroid binding domain of the estrogen receptor (Myc-ER) blocked both the inhibition of FasL and the decrease of AICD induced by TGFb1, providing that 4-hydroxytamoxifen was present. These results identify one mechanism by which TGFb1 blocks AICD to allow the clonal expansion of effector T cells and the generation of memory T cells during immune responses.</dcterms:abstract>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-10-24T12:49:11Z</dcterms:available>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:language>eng</dc:language>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/14303/2/1999_Genestier_Transforming%20Growth%20Factor.pdf"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:contributor>Kasibhatla, Shailaja</dc:contributor>
    <dc:creator>Brunner, Thomas</dc:creator>
    <dcterms:issued>1999</dcterms:issued>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:rights>terms-of-use</dc:rights>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
Begutachtet
Diese Publikation teilen