Publikation: Male and female Wistar rats differ in decision-making performance in a rodent version of the Iowa Gambling Task
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The Iowa Gambling Task (IGT) measures decision-making processes by simulating real-life decisions involving reward, punishment, and uncertainty of outcomes. In humans, men show more choices for the advantageous option than women. Here, we investigated sex differences in a rat model of the IGT (r-IGT). In our r-IGT mildly food-deprived rats learn to differentiate a long-term advantageous arm from a long-term disadvantageous arm differing in frequency and amount of sugar pellets as well as unpalatable but not uneatable quinine-treated sugar pellets. We also used a T-maze discrimination procedure in which rats learn to differentiate a high from a low reward arm to further explore sex differences in reward-related decision-making. In line with human data, male rats showed a stronger task progression of choices for the advantageous option than female rats. Furthermore, male rats showed more win-stay and less lose-shift behaviour in the advantageous arm as the task progressed than female rats. Whilst both male and female rats had a stronger preference for the high over the small reward arm in the T-maze, males increased this preference over sessions, whilst females did not. These data are discussed in relation to sex differences in processing rewards and punishments.
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VAN DEN BOS, Ruud, Jolle JOLLES, Lisette VAN DER KNAAP, Annemarie BAARS, Leonie DE VISSER, 2012. Male and female Wistar rats differ in decision-making performance in a rodent version of the Iowa Gambling Task. In: Behavioural Brain Research. 2012, 234(2), pp. 375-379. ISSN 0166-4328. eISSN 1872-7549. Available under: doi: 10.1016/j.bbr.2012.07.015BibTex
@article{vandenBos2012-10-01femal-46197,
year={2012},
doi={10.1016/j.bbr.2012.07.015},
title={Male and female Wistar rats differ in decision-making performance in a rodent version of the Iowa Gambling Task},
number={2},
volume={234},
issn={0166-4328},
journal={Behavioural Brain Research},
pages={375--379},
author={van den Bos, Ruud and Jolles, Jolle and van der Knaap, Lisette and Baars, Annemarie and de Visser, Leonie}
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