Publikation:

Investigation on the electrochemistry and cytotoxicity of the natural product marcanine A and its synthetic derivatives

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Jacobs_0-301160.pdf
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Datum

2015

Autor:innen

Jacobs, Nadine
Panisch, Robin
Wittstock, Gunther
Nasiri, Hamid R.

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URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-0-301160
DOI (zitierfähiger Link)
https://doi.org/10.1039/C5RA11078E
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Open Access-Veröffentlichung
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Chemie: Publikationen
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Published

Erschienen in

RSC Advances. 2015, 5(72), pp. 58561-58565. eISSN 2046-2069. Available under: doi: 10.1039/C5RA11078E

Zusammenfassung

The electrochemistry and cytotoxicity of marcanine A were investigated by electrochemical, computational and cellular studies. To enable a structure–toxicity-relationship of the natural product, eleven novel synthetic derivatives with different electrochemical properties were synthesized and tested. Derivative 5 revealed a GI50 in the low μM range, being more active than the actual natural product. A clear correlation was found between the experimental and the calculated data.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
540 Chemie

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ISO 690JACOBS, Nadine, Steffen LANG, Robin PANISCH, Gunther WITTSTOCK, Ulrich GROTH, Hamid R. NASIRI, 2015. Investigation on the electrochemistry and cytotoxicity of the natural product marcanine A and its synthetic derivatives. In: RSC Advances. 2015, 5(72), pp. 58561-58565. eISSN 2046-2069. Available under: doi: 10.1039/C5RA11078E
BibTex
@article{Jacobs2015Inves-32598,
  year={2015},
  doi={10.1039/C5RA11078E},
  title={Investigation on the electrochemistry and cytotoxicity of the natural product marcanine A and its synthetic derivatives},
  number={72},
  volume={5},
  journal={RSC Advances},
  pages={58561--58565},
  author={Jacobs, Nadine and Lang, Steffen and Panisch, Robin and Wittstock, Gunther and Groth, Ulrich and Nasiri, Hamid R.}
}
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