Investigation on the electrochemistry and cytotoxicity of the natural product marcanine A and its synthetic derivatives

Jacobs, Nadine; Lang, Steffen; Panisch, Robin; Wittstock, Gunther; Groth, Ulrich; Nasiri, Hamid R.

Investigation on the electrochemistry and cytotoxicity of the natural product marcanine A and its synthetic derivatives

Files

Jacobs_0-301160.pdf(418.25 KB)

Date

2015

Authors

Jacobs, Nadine

Lang, Steffen

Panisch, Robin

Wittstock, Gunther

Groth, Ulrich

Nasiri, Hamid R.

Publication type

Journal article

Publication status

Published

Published in

RSC Advances ; 5 (2015), 72. - pp. 58561-58565. - eISSN 2046-2069

Abstract

The electrochemistry and cytotoxicity of marcanine A were investigated by electrochemical, computational and cellular studies. To enable a structure–toxicity-relationship of the natural product, eleven novel synthetic derivatives with different electrochemical properties were synthesized and tested. Derivative 5 revealed a GI50 in the low μM range, being more active than the actual natural product. A clear correlation was found between the experimental and the calculated data.

Subject (DDC)

540 Chemistry

Cite This

ISO 690

JACOBS, Nadine, Steffen LANG, Robin PANISCH, Gunther WITTSTOCK, Ulrich GROTH, Hamid R. NASIRI, 2015. Investigation on the electrochemistry and cytotoxicity of the natural product marcanine A and its synthetic derivatives. In: RSC Advances. 5(72), pp. 58561-58565. eISSN 2046-2069. Available under: doi: 10.1039/C5RA11078E

BibTex

@article{Jacobs2015Inves-32598,
  year={2015},
  doi={10.1039/C5RA11078E},
  title={Investigation on the electrochemistry and cytotoxicity of the natural product marcanine A and its synthetic derivatives},
  number={72},
  volume={5},
  journal={RSC Advances},
  pages={58561--58565},
  author={Jacobs, Nadine and Lang, Steffen and Panisch, Robin and Wittstock, Gunther and Groth, Ulrich and Nasiri, Hamid R.}
}

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