Cytotoxic dinuclear titanium-salan complexes : structural and biological characterization

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2012
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Journal of Inorganic Biochemistry. 2012, 106(1), pp. 68-75. ISSN 0162-0134. eISSN 1873-3344. Available under: doi: 10.1016/j.jinorgbio.2011.08.029
Zusammenfassung

Controlled hydrolysis of donor-substituted titanium-salan complexes led to the formation of well-defined dinuclear complexes. Structure determination by means of X-ray and NMR-studies revealed the presence of a single My-oxo bridge and one labile alkoxide ligand per titanium center. Concomitant cytotoxicity assays of the isolated dinuclear complexes showed cytotoxicities in the low micro-molar region, surpassing in this respect even their monomeric ancestors, thus making them possible highly active metabolites of titanium-salan anti-cancer drugs.

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540 Chemie
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Dinuclear complexes, titanium salan complexes, hydrolysis, antitumor agents, cytotoxicity
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ISO 690IMMEL, Timo, Martin GRÜTZKE, Ellen BATROFF, Ulrich GROTH, Thomas HUHN, 2012. Cytotoxic dinuclear titanium-salan complexes : structural and biological characterization. In: Journal of Inorganic Biochemistry. 2012, 106(1), pp. 68-75. ISSN 0162-0134. eISSN 1873-3344. Available under: doi: 10.1016/j.jinorgbio.2011.08.029
BibTex
@article{Immel2012-01Cytot-17935,
  year={2012},
  doi={10.1016/j.jinorgbio.2011.08.029},
  title={Cytotoxic dinuclear titanium-salan complexes : structural and biological characterization},
  number={1},
  volume={106},
  issn={0162-0134},
  journal={Journal of Inorganic Biochemistry},
  pages={68--75},
  author={Immel, Timo and Grützke, Martin and Batroff, Ellen and Groth, Ulrich and Huhn, Thomas}
}
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