Publikation: Non-canonical functions of BCL-2 family members in energy metabolism and necrotic cell death regulation
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2025
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Open Access-Veröffentlichung
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Core Facility der Universität Konstanz
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Published
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Cell Cycle. Taylor & Francis, S. 1-18. ISSN 1538-4101. eISSN 1551-4005. Verfügbar unter: doi: 10.1080/15384101.2025.2484868
Zusammenfassung
The large family of BCL-2 proteins plays a well-established role in the regulation of mitochondrial apoptosis pathway, and the crosstalk between death receptor signaling and mitochondrial apoptosis. Accumulating evidence suggests, however, that various BCL-2 family members are also involved in the regulation of apoptosis-unrelated necrotic forms of cell death, and even noncell death processes. In this review, we discuss the emerging role of BCL-2 family members, and in particular BIM, in the regulation of mitochondrial dynamics, morphology and energy metabolism, and associated consequences for drug-inuced necrotic cell death.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
BCL-2, apoptosis, mitochondria, electron transport chain, glycolysis, mitotoxicants
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EL-MESERY, Mohamed, Franziska RUDOLF, Yannick HEIMANN, Georg HÄCKER, Thomas BRUNNER, 2025. Non-canonical functions of BCL-2 family members in energy metabolism and necrotic cell death regulation. In: Cell Cycle. Taylor & Francis, S. 1-18. ISSN 1538-4101. eISSN 1551-4005. Verfügbar unter: doi: 10.1080/15384101.2025.2484868BibTex
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title={Non-canonical functions of BCL-2 family members in energy metabolism and necrotic cell death regulation},
year={2025},
doi={10.1080/15384101.2025.2484868},
issn={1538-4101},
journal={Cell Cycle},
pages={1--18},
author={El-Mesery, Mohamed and Rudolf, Franziska and Heimann, Yannick and Häcker, Georg and Brunner, Thomas}
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<dcterms:abstract>The large family of BCL-2 proteins plays a well-established role in the regulation of mitochondrial apoptosis pathway, and the crosstalk between death receptor signaling and mitochondrial apoptosis. Accumulating evidence suggests, however, that various BCL-2 family members are also involved in the regulation of apoptosis-unrelated necrotic forms of cell death, and even noncell death processes. In this review, we discuss the emerging role of BCL-2 family members, and in
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