Publikation:

The Microbiome as a Circadian Coordinator of Metabolism

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2020

Autor:innen

Alvarez, Yelina
Glotfelty, Lila G.
Dohnalová, Lenka
Thaiss, Christoph A.

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Open Access-Veröffentlichung
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Endocrinology. Oxford University Press. 2020, 161(6), bqaa059. ISSN 0013-7227. eISSN 1945-7170. Available under: doi: 10.1210/endocr/bqaa059

Zusammenfassung

The microbiome is critically involved in the regulation of systemic metabolism. An important but poorly understood facet of this regulation is the diurnal activity of the microbiome. Herein, we summarize recent developments in our understanding of the diurnal properties of the microbiome and their integration into the circadian regulation of organismal metabolism. The microbiome may be involved in the detrimental consequences of circadian disruption for host metabolism and the development of metabolic disease. At the same time, the mechanisms by which microbiome diurnal activity is integrated into host physiology reveal several translational opportunities by which the time of day can be harnessed to optimize microbiome-based therapies. The study of circadian microbiome properties may thus provide a new avenue for treating disorders associated with circadian disruption from the gut.

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Fachgebiet (DDC)
540 Chemie

Schlagwörter

microbiome, circadian rhythm, metabolism

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ISO 690ALVAREZ, Yelina, Lila G. GLOTFELTY, Niklas BLANK, Lenka DOHNALOVÁ, Christoph A. THAISS, 2020. The Microbiome as a Circadian Coordinator of Metabolism. In: Endocrinology. Oxford University Press. 2020, 161(6), bqaa059. ISSN 0013-7227. eISSN 1945-7170. Available under: doi: 10.1210/endocr/bqaa059
BibTex
@article{Alvarez2020-06-01Micro-50350,
  year={2020},
  doi={10.1210/endocr/bqaa059},
  title={The Microbiome as a Circadian Coordinator of Metabolism},
  number={6},
  volume={161},
  issn={0013-7227},
  journal={Endocrinology},
  author={Alvarez, Yelina and Glotfelty, Lila G. and Blank, Niklas and Dohnalová, Lenka and Thaiss, Christoph A.},
  note={Article Number: bqaa059}
}
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