Publikation:

Expression and subcellular localization of mouse 20S proteasome activator complex PA28

Lade...
Vorschaubild

Dateien

Zu diesem Dokument gibt es keine Dateien.

Datum

1997

Autor:innen

Soza, Andrea
Knuehl, Christine
Henklein, Peter
Tanaka, Keiji
Kloetzel, Peter M.

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

ArXiv-ID

Internationale Patentnummer

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

FEBS Letters. 1997, 413(1), pp. 27-34. ISSN 0014-5793. eISSN 1873-3468. Available under: doi: 10.1016/S0014-5793(97)00864-8

Zusammenfassung

We have cloned the mouse PA28 proteasome activator cDNAs. Northern blot demonstrates high PA28 mRNA levels in liver, kidney and lung. mRNA levels are low in thymus, spleen and brain. In contrast, PA28 protein levels vary little between these tissues. Immunocytological analysis and cell fractionation experiments demonstrate that both subunits are almost equally distributed between the cytoplasm and the nucleus. Interestingly, PA28alpha spares nucleoli, while PA28beta is strongly enhanced in the nucleolus. This indicates for the first time that the PA28alpha and PA28beta subunits may serve nuclear functions which may be different from and independent of each other.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Proteasome, Activator, Ki-autoantigen

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690SOZA, Andrea, Christine KNUEHL, Marcus GRÖTTRUP, Peter HENKLEIN, Keiji TANAKA, Peter M. KLOETZEL, 1997. Expression and subcellular localization of mouse 20S proteasome activator complex PA28. In: FEBS Letters. 1997, 413(1), pp. 27-34. ISSN 0014-5793. eISSN 1873-3468. Available under: doi: 10.1016/S0014-5793(97)00864-8
BibTex
@article{Soza1997Expre-22244,
  year={1997},
  doi={10.1016/S0014-5793(97)00864-8},
  title={Expression and subcellular localization of mouse 20S proteasome activator complex PA28},
  number={1},
  volume={413},
  issn={0014-5793},
  journal={FEBS Letters},
  pages={27--34},
  author={Soza, Andrea and Knuehl, Christine and Gröttrup, Marcus and Henklein, Peter and Tanaka, Keiji and Kloetzel, Peter M.}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/22244">
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:creator>Soza, Andrea</dc:creator>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/22244"/>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:contributor>Knuehl, Christine</dc:contributor>
    <dcterms:bibliographicCitation>FEBS Letters ; 413 (1997), 1. - S. 27-34</dcterms:bibliographicCitation>
    <dcterms:abstract xml:lang="eng">We have cloned the mouse PA28 proteasome activator cDNAs. Northern blot demonstrates high PA28 mRNA levels in liver, kidney and lung. mRNA levels are low in thymus, spleen and brain. In contrast, PA28 protein levels vary little between these tissues. Immunocytological analysis and cell fractionation experiments demonstrate that both subunits are almost equally distributed between the cytoplasm and the nucleus. Interestingly, PA28alpha spares nucleoli, while PA28beta is strongly enhanced in the nucleolus. This indicates for the first time that the PA28alpha and PA28beta subunits may serve nuclear functions which may be different from and independent of each other.</dcterms:abstract>
    <dc:contributor>Kloetzel, Peter M.</dc:contributor>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:rights>terms-of-use</dc:rights>
    <dc:contributor>Soza, Andrea</dc:contributor>
    <dc:contributor>Gröttrup, Marcus</dc:contributor>
    <dc:creator>Henklein, Peter</dc:creator>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-04-02T18:48:06Z</dcterms:available>
    <dc:creator>Kloetzel, Peter M.</dc:creator>
    <dc:contributor>Henklein, Peter</dc:contributor>
    <dc:creator>Tanaka, Keiji</dc:creator>
    <dc:creator>Knuehl, Christine</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-04-02T18:48:06Z</dc:date>
    <dc:creator>Gröttrup, Marcus</dc:creator>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:contributor>Tanaka, Keiji</dc:contributor>
    <dc:language>eng</dc:language>
    <dcterms:title>Expression and subcellular localization of mouse 20S proteasome activator complex PA28</dcterms:title>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dcterms:issued>1997</dcterms:issued>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
Begutachtet
Diese Publikation teilen