Publikation:

Modified hammerhead ribozymes as potential therapeutics

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Modified_Hammerhead_Ribozymes_as_Potential_Therapeutics.pdf
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Datum

1998

Autor:innen

Engels, Joachim W.
Scherr, Michaela
Ganser, Arnold
Grez, Manuel

Herausgeber:innen

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URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-44059
DOI (zitierfähiger Link)
https://doi.org/10.1080/07328319808004702
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Link zur Lizenz
Attribution-NonCommercial-NoDerivs 2.0 Generic

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Open Access-Veröffentlichung
Open Access Green

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Chemie: Publikationen
Core Facility der Universität Konstanz

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Zeitschriftenartikel
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Published

Erschienen in

Nucleosides and Nucleotides. 1998, 17(9-11), pp. 1685-1696. ISSN 0732-8311. Available under: doi: 10.1080/07328319808004702

Zusammenfassung

Hammerhead ribozymes were modified in the 2'-position by flouro-, amino-, deoxy-, 0-methyl- and methoxyethoxy-grmps to stabilize against degradations. They were tested for their ability to cut specifically oncogenic N-ras RNA in vitro. Exogenous delivery by lipofection as well as viral vector mediated transfection showed comparable results in reducing N-ras mRNA.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
540 Chemie

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ISO 690ENGELS, Joachim W., Michaela SCHERR, Arnold GANSER, Manuel GREZ, Valentin WITTMANN, 1998. Modified hammerhead ribozymes as potential therapeutics. In: Nucleosides and Nucleotides. 1998, 17(9-11), pp. 1685-1696. ISSN 0732-8311. Available under: doi: 10.1080/07328319808004702
BibTex
@article{Engels1998Modif-9974,
  year={1998},
  doi={10.1080/07328319808004702},
  title={Modified hammerhead ribozymes as potential therapeutics},
  number={9-11},
  volume={17},
  issn={0732-8311},
  journal={Nucleosides and Nucleotides},
  pages={1685--1696},
  author={Engels, Joachim W. and Scherr, Michaela and Ganser, Arnold and Grez, Manuel and Wittmann, Valentin}
}
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