Publikation: Modified hammerhead ribozymes as potential therapeutics
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1998
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Nucleosides and Nucleotides. 1998, 17(9-11), pp. 1685-1696. ISSN 0732-8311. Available under: doi: 10.1080/07328319808004702
Zusammenfassung
Hammerhead ribozymes were modified in the 2'-position by flouro-, amino-, deoxy-, 0-methyl- and methoxyethoxy-grmps to stabilize against degradations. They were tested for their ability to cut specifically oncogenic N-ras RNA in vitro. Exogenous delivery by lipofection as well as viral vector mediated transfection showed comparable results in reducing N-ras mRNA.
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540 Chemie
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ENGELS, Joachim W., Michaela SCHERR, Arnold GANSER, Manuel GREZ, Valentin WITTMANN, 1998. Modified hammerhead ribozymes as potential therapeutics. In: Nucleosides and Nucleotides. 1998, 17(9-11), pp. 1685-1696. ISSN 0732-8311. Available under: doi: 10.1080/07328319808004702BibTex
@article{Engels1998Modif-9974, year={1998}, doi={10.1080/07328319808004702}, title={Modified hammerhead ribozymes as potential therapeutics}, number={9-11}, volume={17}, issn={0732-8311}, journal={Nucleosides and Nucleotides}, pages={1685--1696}, author={Engels, Joachim W. and Scherr, Michaela and Ganser, Arnold and Grez, Manuel and Wittmann, Valentin} }
RDF
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