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Toward Semisynthetic Lipoproteins by Convergent Strategies Based on Click and Ligation Chemistry

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2005

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Musiol, Hans-Jürgen
Dong, Shouliang
Kaiser, Markus
Bertsch, Uwe
Moroder, Luis

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https://doi.org/10.1002/cbic.200400351
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ChemBioChem. 2005, 6(4), pp. 625-628. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.200400351

Zusammenfassung

A new convergent strategy is proposed for the semisynthesis of C‐terminally lipidated proteins that is based on the copper(I)‐catalyzed 1,3‐dipolar cycloaddition of terminal alkynes in synthetic peptides to dimyristoylphosphatidylethanol azide followed by native chemical ligation (NCL) or expressed protein ligation (EPL) of the lipopeptide with synthetic or expressed polypeptide thioesters.

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540 Chemie

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ISO 690MUSIOL, Hans-Jürgen, Shouliang DONG, Markus KAISER, Ralf BAUSINGER, Andreas ZUMBUSCH, Uwe BERTSCH, Luis MORODER, 2005. Toward Semisynthetic Lipoproteins by Convergent Strategies Based on Click and Ligation Chemistry. In: ChemBioChem. 2005, 6(4), pp. 625-628. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.200400351
BibTex
@article{Musiol2005-04Towar-42311,
  year={2005},
  doi={10.1002/cbic.200400351},
  title={Toward Semisynthetic Lipoproteins by Convergent Strategies Based on Click and Ligation Chemistry},
  number={4},
  volume={6},
  issn={1439-4227},
  journal={ChemBioChem},
  pages={625--628},
  author={Musiol, Hans-Jürgen and Dong, Shouliang and Kaiser, Markus and Bausinger, Ralf and Zumbusch, Andreas and Bertsch, Uwe and Moroder, Luis}
}
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