Do H+ ions obscure electrogenic Na+ and K+ binding in the E1 state of the Na,K-ATPase?

Kurzanzeige
dc.contributor.authorApell, Hans-Jürgen
dc.contributor.authorDiller, Annadeu
dc.date.accessioned2011-03-24T17:38:15Zdeu
dc.date.available2011-03-24T17:38:15Zdeu
dc.date.issued2002deu
dc.description.abstractIn contrast to other P-type ATPases, the Na,K-ATPase binding and release of ions on the cytoplasmic side, to the state called E1, is not electrogenic with the exception of the third Na+. Since the high-resolution structure of the closely related SR Ca-ATPase in state E1 revealed the ion-binding sites deep inside the transmembrane part of the protein, the missing electrogenicity in state E1 can be explained by an obscuring counter-movement of H+ ions. Evidence for such a mechanism is presented by analysis of pH effects of Na+ and K+ binding and by electrogenic H+ movements in the E1 conformation of the Na,K-ATPase.eng
dc.description.versionpublished
dc.format.mimetypeapplication/pdfdeu
dc.identifier.citationFirst publ. in: FEBS Letters 532 (2002), pp. 198-202deu
dc.identifier.doi10.1016/S0014-5793(02)03675-X
dc.identifier.ppn274133261deu
dc.identifier.urihttp://kops.uni-konstanz.de/handle/123456789/7883
dc.language.isoengdeu
dc.legacy.dateIssued2007deu
dc.rightsAttribution-NonCommercial-NoDerivs 2.0 Generic
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.0/
dc.subjectActive ion transportdeu
dc.subjectSodium mumpdeu
dc.subjectBinding sitesdeu
dc.subjectelectrogenicitydeu
dc.subjectCompetitiondeu
dc.subject.ddc570deu
dc.titleDo H+ ions obscure electrogenic Na+ and K+ binding in the E1 state of the Na,K-ATPase?eng
dc.typeJOURNAL_ARTICLEdeu
dspace.entity.typePublication
kops.citation.bibtex
@article{Apell2002obscu-7883,
  year={2002},
  doi={10.1016/S0014-5793(02)03675-X},
  title={Do H+ ions obscure electrogenic Na+ and K+ binding in the E1 state of the Na,K-ATPase?},
  number={1-2},
  volume={532},
  issn={0014-5793},
  journal={FEBS Letters},
  pages={198--202},
  author={Apell, Hans-Jürgen and Diller, Anna}
}
kops.citation.iso690APELL, Hans-Jürgen, Anna DILLER, 2002. Do H+ ions obscure electrogenic Na+ and K+ binding in the E1 state of the Na,K-ATPase?. In: FEBS Letters. 2002, 532(1-2), pp. 198-202. ISSN 0014-5793. Available under: doi: 10.1016/S0014-5793(02)03675-Xdeu
kops.citation.iso690APELL, Hans-Jürgen, Anna DILLER, 2002. Do H+ ions obscure electrogenic Na+ and K+ binding in the E1 state of the Na,K-ATPase?. In: FEBS Letters. 2002, 532(1-2), pp. 198-202. ISSN 0014-5793. Available under: doi: 10.1016/S0014-5793(02)03675-Xeng
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