Publikation:

Recommendations on fit-for-purpose criteria to establish quality management for microphysiological systems and for monitoring their reproducibility

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Datum

2024

Autor:innen

Pamies, David
Ekert, Jason
Zurich, Marie-Gabrielle
Frey, Olivier
Werner, Sophie
Piergiovanni, Monica
Freedman, Benjamin S.
Keong Teo, Adrian Kee
et al.

Herausgeber:innen

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Angaben zur Forschungsförderung

European Union (EU): 964537
European Union (EU): 964518
European Union (EU): 101057014
Institutionen der Bundesrepublik Deutschland: INVITE2

Projekt

RISK-HUNT3R
PARC: Partnership for the Assessment of Risks from Chemicals
Open Access-Veröffentlichung
Open Access Gold
Core Facility der Universität Konstanz

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Titel in einer weiteren Sprache

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Published

Erschienen in

Stem Cell Reports. Elsevier. 2024, 19(5), S. 604-617. eISSN 2213-6711. Verfügbar unter: doi: 10.1016/j.stemcr.2024.03.009

Zusammenfassung

Cell culture technology has evolved, moving from single-cell and monolayer methods to 3D models like reaggregates, spheroids, and organoids, improved with bioengineering like microfabrication and bioprinting. These advancements, termed microphysiological systems (MPSs), closely replicate tissue environments and human physiology, enhancing research and biomedical uses. However, MPS complexity introduces standardization challenges, impacting reproducibility and trust. We offer guidelines for quality management and control criteria specific to MPSs, facilitating reliable outcomes without stifling innovation. Our fit-for-purpose recommendations provide actionable advice for achieving consistent MPS performance.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

microphysiological systems, organoids, organ on chip, spheroids, reproducibility, quality control, standards, criteria, recommendations, in vitro

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Zitieren

ISO 690PAMIES, David, Jason EKERT, Marie-Gabrielle ZURICH, Olivier FREY, Sophie WERNER, Monica PIERGIOVANNI, Benjamin S. FREEDMAN, Adrian Kee KEONG TEO, Thomas HARTUNG, Marcel LEIST, 2024. Recommendations on fit-for-purpose criteria to establish quality management for microphysiological systems and for monitoring their reproducibility. In: Stem Cell Reports. Elsevier. 2024, 19(5), S. 604-617. eISSN 2213-6711. Verfügbar unter: doi: 10.1016/j.stemcr.2024.03.009
BibTex
@article{Pamies2024-05Recom-69980,
  year={2024},
  doi={10.1016/j.stemcr.2024.03.009},
  title={Recommendations on fit-for-purpose criteria to establish quality management for microphysiological systems and for monitoring their reproducibility},
  number={5},
  volume={19},
  journal={Stem Cell Reports},
  pages={604--617},
  author={Pamies, David and Ekert, Jason and Zurich, Marie-Gabrielle and Frey, Olivier and Werner, Sophie and Piergiovanni, Monica and Freedman, Benjamin S. and Keong Teo, Adrian Kee and Hartung, Thomas and Leist, Marcel}
}
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Interner Vermerk

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