Publikation:

Structurally Refined beta-Lactones as Potent Inhibitors of Devastating Bacterial Virulence Factors

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2009

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Sieber, Stephan A.

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http://nbn-resolving.de/urn:nbn:de:bsz:352-284476
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https://doi.org/10.1002/cbic.200800743
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ChemBioChem. 2009, 10(4), pp. 663-666. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.200800743

Zusammenfassung

Disarmed forces: Inhibition of the central virulence regulator ClpP by structurally refined beta-lactones resulted in dramatically reduced production of devastating virulence factors, including pyrogenic toxin superantigens derived from pathogenic multiresistant Staphylococcus aureus strains. Targeting of this virulence regulator could present an attractive strategy for neutralizing the harmful effects of bacterial pathogens, and help the host immune response to eliminate the disarmed bacteria.

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540 Chemie

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ISO 690BÖTTCHER, Thomas, Stephan A. SIEBER, 2009. Structurally Refined beta-Lactones as Potent Inhibitors of Devastating Bacterial Virulence Factors. In: ChemBioChem. 2009, 10(4), pp. 663-666. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.200800743
BibTex
@article{Bottcher2009-03-02Struc-28447,
  year={2009},
  doi={10.1002/cbic.200800743},
  title={Structurally Refined beta-Lactones as Potent Inhibitors of Devastating Bacterial Virulence Factors},
  number={4},
  volume={10},
  issn={1439-4227},
  journal={ChemBioChem},
  pages={663--666},
  author={Böttcher, Thomas and Sieber, Stephan A.}
}
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